Cell contact inhibition

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The contact inhibition , and contact inhibition called, refers to the property of cells , the cell growth and cell division set from a certain cell density.

properties

The cell contact inhibition is mediated by cell adhesion molecules during cell-cell contact . This is intended to achieve homeostasis of the cell network of a fully developed living being or, in the event of injuries, tissue to be partially replaced in the course of wound healing .

Normal cells in cell cultures have an optimal cell density for growth, below this an anoikis can lead to premature cell death , growth and division are stopped above this. Certain cell densities in a cell culture that are low in comparison to tissue have the highest growth rate, limited only by the Hayflick limit . The higher the cell density, the less a cell can expand without coming into contact with other cells. Depending on the cell type , cell-cell contacts stop growth in one or both cells of a cell-cell contact.

In tumor cells , the contact inhibition is often overridden by mutations , which results in uncontrolled growing cell clusters. Monolayers are no longer complied with. Naked mole rats never get cancer , which is possibly due to a particularly pronounced inhibition of cell contact.

In some immortalized cell lines , cell contact inhibition works partially.

Individual evidence

  1. ↑ Jennie Dushek, Allen J. Tobin: Asking About Life. 1st edition. Belmont: Brooks / Cole-Thomson Learning, 2005. ISBN 9780534406530 . P. 161.
  2. ^ William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino: Concepts of Genetics . 10th edition, 2011, Pearson, San Francisco. ISBN 978-0321724120 .
  3. ^ RJ Wieser, D. Renauer, A. Schäfer, R. Heck, R. Engel, S. Schütz, F. Oesch: Growth control in mammalian cells by cell-cell contacts. In: Environmental health perspectives. Volume 88, August 1990, ISSN  0091-6765 , pp. 251-253, PMID 2272319 , PMC 1567996 (free full text) (review).
  4. ^ John M. Lackie, Julian AT Dow: The Dictionary of Cell & Molecular Biology . 3rd edition, 1999, Academic Press. ISBN 9780124325654 .
  5. ↑ Seluanov A, Hine C, Azpurua J, Feigenson M, Bozzella M, Mao Z, Catania KC, Gorbunova V: Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat . In: Proc Natl Acad Sci USA . 106, No. 46, 2009, pp. 19352-7. doi : 10.1073 / pnas.0905252106 . PMID 19858485 . PMC 2780760 (free full text).
  6. ↑ M. Abercrombie: Contact inhibition and malignancy . In: Nature . 281, No. 5729, September 27, 1979, pp. 259-262. Retrieved February 1, 2013.