Corrected transposition of the great arteries
| Classification according to ICD-10 | |
|---|---|
| Q20.5 | Discordant atrioventricular connection - Corrected transposition of the great vessels |
| Q24.1 | Levocardia The heart is in the left half of the thorax, the apex points to the left; but this situation is connected with a situs inversus of other organs, with other malformations of the heart, or with a corrected transposition of the great vessels. |
| ICD-10 online (WHO version 2019) | |
The corrected transposition of the great arteries (CTGA or ccTGA - Congenitally Corrected Transposition
of the Great Arteries, also known as l-TGA or laevo- transposition of the great arteries ) is a seldom occurring complex malformation of the human heart in which the two ventricles ( heart chambers ) are exchanged: the atria are "wrong" "Ventricles connected, the large arteries also originate from the" wrong "ventricles (transposition). This double swap (in contrast to the TGA ) ensures a functioning blood circulation and the child is not cyanotic (lack of oxygen). This clinical picture is often combined with other defects (valve malformations, pulmonary stenosis , ventricular septal defect , mitral valve insufficiency ).
The symptoms can be mild (in some cases the child appears healthy) to severe (increasing shortness of breath, no weight gain in the first weeks after birth) and depend on the individual severity.
The main problem here is the overloading of the morphologically right (functionally left) ventricle, which has to maintain the body's circulation. A relevant additional ventricular septal defect (shunt) can lead to long-term problematic increased pulmonary blood pressure. Without significant accompanying heart defects, symptoms can sometimes only appear in adulthood.
For several years, the (technically demanding) "double switch" operation has been carried out several times, in which the large arteries are diverted so that the normal flow of blood through the ventricles is established. Long-term data on this operation are not available.
literature
- P. Martins, E. Castela: Transposition of the great arteries. In: Orphanet J Rare Dis. 3, Oct 13, 2008, p. 27. PMID 18851735 , PMC 2577629 (free full text)
