Letts nitrile synthesis

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The Letts nitrile synthesis is the reaction of aromatic carboxylic acids with metal thiocyanates (e.g. potassium thiocyanate ), which enables the production of aromatic nitriles . The British chemist Edmund A. Letts (1852–1918) first described this reaction, which was later named after him. Using the example of the conversion of benzoic acid , the reaction equation reads:

Letts nitrile synthesis V.1.png

literature

  • EA Letts: New Formations of Amides and Nitriles . In: Reports of the German Chemical Society . tape 5 , no. 2 , July 1, 1872, p. 669-674 , doi : 10.1002 / cber.18720050228 .
  • Gerhard Krüss: About a new representation method for nitriles . In: Reports of the German Chemical Society . tape 17 , no. 2 , July 1, 1884, p. 1766–1768 , doi : 10.1002 / cber.18840170245 .
  • EE Reid: Studies in the Preparation of Nitriles . In: Am. Chem. J. Volume 43 , 1910, pp. 162-181 ( Internet Archive ).
  • GD van Epps, E. Emmet Reid: Studies in the Preparation of Nitriles. II. The Preparation of. Aliphatic nitriles . In: Journal of the American Chemical Society . tape 38 , no. 10 , October 1, 1916, p. 2120–2128 , doi : 10.1021 / ja02267a022 .
  • David T. Mowry: The Preparation of Nitriles . In: Chemical Reviews . tape 42 , no. 2 , April 1, 1948, p. 189-283 , doi : 10.1021 / cr60132a001 .
  • F. Klages: Textbook of organic chemistry I . Berlin 1959, p. 362.