Leuchs' anhydrides
Leuchs' anhydride is the name of a group of substances with the basic chemical structure of oxazolidine -2,5-diones.
The compounds were first described by Hermann Leuchs and are internal anhydrides of amino acids . Leuchs described the synthesis using the N -carboxylic acid anhydride method he developed . For example, they can be prepared from the amino acids by reaction with phosgene . Because of their reactivity, they are used as building blocks for synthesis. B. used in peptide synthesis .
swell
- Thomas Kurz: Five-membered heterocyclic bond systems made from functionalized malonic acid esters. Synthesis, reactivity and biological properties . University of Hamburg, dissertation 1999, online (PDF; 783 kB) .
- Hermann Leuchs: About the glycine carboxylic acid . In: Reports of the German Chemical Society 39, 1906, 1, pp. 857-861, doi : 10.1002 / cber.190603901133 .
Individual evidence
- ↑ Hans-Dieter Jakubke, Hans Jeschkeit: Amino acids, peptides, proteins. Verlag Chemie, Weinheim, pp. 164-166, 1982, ISBN 3-527-25892-2 .