Lobelia alkaloids

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Loyal to men ( Lobelia erinus )
Lobelia ( Lobelia inflata )

Lobelia alkaloids are natural substances that occur in lobelia of a genus of plants within the bluebell family, particularly Lobelia inflata . They are disubstituted piperidine alkaloids that can be obtained by extraction.

Occurrence

Lobelia contain up to 0.3% lobelia alkaloids.

Representative

There are around 20 lobelia alkaloids. The main representative is the lobelin . The other lobelia alkaloids often differ from lobeline in having an oxidized hydroxyl group or a reduced carbonyl group. Other representatives include lelobanidine and lobelanidine , in which the carbonyl group has been reduced to the hydroxyl group. Furthermore lobinanidine and isolobinin . The lobinin group within the lobelia alkaloids describes alkaloids that contain a tetrahydropyridine ring. This includes, for example, lobinaline .

  • Lobeline

  • Lelobanidine

  • Lobelanidin

  • Lobinanidine

  • Isolobinin

use

Lobelia alkaloids are used in homeopathy for asthma, hyperemesis, nausea with fear of death and cold sweats.

Individual evidence

  1. ^ A b Louis Fieser , Mary Fieser: Organische Chemie , Verlag Chemie Weinheim, 2nd edition, 1972, ISBN 3-527-25075-1 , pp. 1488-1489.
  2. ↑ G. Habermehl, P. Hammann, H. Krebs: Naturstoffchemie . 2nd Edition. Springer-Verlag, Berlin Heidelberg 2002, ISBN 978-3-540-43952-3 , p. 139 ff .
  3. ↑ a b Entry on Lobelia alkaloids. In: Römpp Online . Georg Thieme Verlag, accessed on April 14, 2020.
  4. ^ P. Nuhn: Naturstoffchemie . 4th edition. S. Hirzel Verlag, Stuttgart 2006, ISBN 978-3-7776-1363-5 , p. 586 .
  5. ↑ a b J. Falbe and M. Regitz: RÖMPP Lexikon Chemie . 10th edition. Georg Thieme Verlag, Stuttgart 1999, ISBN 978-3-540-43952-3 , p. 2433 .