Lymphangiogenesis

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Lymphangiogenesis is the growth of new lymph vessels from existing vessels similar to the process of angiogenesis (growth of blood vessels). The process of lymph vasculogenesis (the de novo formation of lymphatic structures from precursor cells) must be distinguished from this.

Lymphangiogenesis plays an important physiological role in homeostasis , metabolism and immunity . The insufficient or increased formation of lymph vessels is characteristic of a number of diseases, such as: Eg for tumor - metastasis , lymphedema , lipoedema , rheumatoid arthritis , psoriasis , Lymphangiomatosis and delayed wound healing .

The role of the lymphatic system in these diseases has rekindled interest in lymphangiogenesis, not least due to the discovery of markers specific for lymphatic endothelial cells , such as the receptor of the vascular endothelial cell growth factor C VEGF-C ( VEGFR-3 ), podoplanin , LYVE1 , PROX-1 and Desmoplakin . These specific markers enabled new insights into the function, structure and molecular biological basis of the lymphatic system. Several factors are known to stimulate lymphangiogenesis, including VEGF-C, hyaluronic acid and Ephrin-B2 .

literature

  • Karl H. Plate: From angiogenesis to lymphangiogenesis . In: Nature Medicine . tape 7 , no. 2 , February 2001, p. 151-152 , doi : 10.1038 / 84579 .
  • Gavin Jell, Dontscho Kerjaschki, Peter Revell, Najat Al-Saffar: Lymphangiogenesis in the bone-implant interface of orthopedic implants: Importance and consequence . In: Journal of Biomedical Materials Research Part A . 77A, no. 1 , 2006, p. 119-127 , doi : 10.1002 / jbm.a.30548 .
  • Rui-Cheng Ji: Lymphatic Endothelial Cells, Lymphangiogenesis, and Extracellular Matrix . In: Lymphatic Research and Biology . tape 4 , no. 2 , June 1, 2006, p. 83-100 , doi : 10.1089 / lrb.2006.4.83 .
  • Sawan Kumar Jha, Khushbu Rauniyar, Michael Jeltsch: Key molecules in lymphatic development, function, and identification . In: Annals of Anatomy - Anatomischer Anzeiger . tape 219 , 2018, p. 25–34 , doi : 10.1016 / j.aanat.2018.05.003 . (Review article on the markers of lymphatic endothelial cells).

Individual evidence

  1. ↑ Rainer Krebs, Michael Jeltsch: The lymphangiogenic growth factors VEGF-C and VEGF-D. Part 1: Basics and embryonic development . In: Lymphology in Research and Practice . 17, No. 1, 2013, pp. 30-37.
  2. ↑ Kenny Mattonet, Michael Jeltsch: About the heterogeneous origin of the lymphatic system . In: Lymphology in Research and Practice . 19, No. 1, 2015, pp. 84-88.
  3. ↑ Steven A. Stacker: Lymphangiogenesis in Cancer Metastasis . Springer, July 1, 2009, ISBN 978-90-481-2246-2 , pp. 27 ff (accessed on June 26, 2010).