LYVE1
| Endothelial hyaluronic acid receptor 1 of the lymph vessels | ||
|---|---|---|
| Mass / length primary structure | 35 kilodaltons / 322 amino acids | |
| Isoforms | 1 | |
| Identifier | ||
| Gene name (s) | LYVE1 HAR; XLKD1; LYVE-1; CRSBP-1 | |
| External IDs | ||
| Orthologue | ||
| human | House mouse | |
| Entrez | 10894 | 114332 |
| Ensemble | ENSG00000133800 | ENSMUSG00000030787 |
| UniProt | Q9Y5Y7 | Q8BHC0 |
| Refseq (mRNA) | NM_006691 | NM_053247 |
| Refseq (protein) | NP_006682 | NP_444477 |
| Gene locus | Chr 11: 10.56 - 10.57 Mb | Chr 7: 110.85 - 110.86 Mb |
| PubMed search | 10894 |
114332
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LYVE1 (endothelial hyaluronic acid receptor 1 of the lymphatic vessels, English: lymphatic vessel endothelial hyaluronic acid receptor 1) is a protein found in mammals that is encoded on the gene of the same name on chromosome 11 ( locus 11p15.4). It is mainly by endothelial cells of lymphatic vessels expressed .
LYVE1 is involved in diseases such as capillary lymphangioma and complete androgen resistance. It is also important for the metabolism of glycosaminoglycans . An important paralogue gene is CD44 . The following transcription factors regulate LYVE1: GR, GR-alpha, Lmo2, Nkx2-5, MZF-1, c-Fos, HOXA5, AREB6, AP-1 and c-Jun.
Individual evidence
- ↑ a b GeneCards LYVE1: online here ; last viewed on March 30, 16