MCPIP1

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MCPIP1 ( English monocyte chemotactic protein-induced protein 1 , dt. Monocyte chemotactic protein-induced protein 1 , syn .: ZC3H12A) is a protein that occurs in human monocytes and plays a role in inflammatory reactions .

classification

MCPIP1 is currently the best studied, of a new group of four proteins from the group of zinc finger proteins. It is encoded by the corresponding CCCH zinc finger family of genes.

Occurrence

MCPIP1 was first detected in the monocytes after they had been treated with the cytokine MCP-1 (Syn .: CCL2, English: monocyte chemotactic protein-1), but it also occurs in macrophages and endothelial cells when they are stimulated by lipopolysaccharides become.

function

MCPIP1 inhibits macrophages , has an anti-inflammatory effect by inhibiting the development of pro-inflammatory cytokines and also appears to play a role in neuroprotection after a stroke.

Individual evidence

  1. ↑ Pappachan E. Kolattukudy, Jianli Niu: Inflammation, Endoplasmic Reticulum Stress, Autophagy, and the Monocyte Chemoattractant Protein-1 / CCR2 Pathway . In: Circulation Research . tape 110 , no. 1 , June 2012, p. 174-189 , doi : 10.1161 / CIRCRESAHA.111.243212 , PMID 22223213 , PMC 3265021 (free full text).
  2. ↑ ZC3H12A zinc finger CCCH-type containing 12A (Homo sapiens (human)). NCBI, Gene ID 80149, Jan. 26, 2014.
  3. ↑ Zhuqing Jin, Jian Liang, Jing Wang, Pappachan E. Kolattukudy: Delayed brain ischemia tolerance induced by electroacupuncture pretreatment is mediated via MCP-induced protein 1 . In: Journal of Neuroinflammation . tape 10 , no. 1 , May 10, 2013, p. 63 , doi : 10.1186 / 1742-2094-10-63 , PMID 23663236 , PMC 3701471 (free full text).