Mannosylation

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The mannosylation is a posttranslational protein modification that the glycosylation counts. A mannose group is attached to a protein.

properties

Mannosylations are among the glycosylations. These are catalyzed by mannosyltransferases . A distinction can be made between O-glycosylations and C-glycosylations.

O-mannosylations are performed by protein O-mannosyltransferases 1 and 2 (PMT) in the endoplasmic reticulum , unlike other O-glycosylations. Gene defects in the genes that code for PMT (POMT1 and POMT2) lead to limb-girdle muscular dystrophy , Walker-Warburg syndrome or muscle-eye-brain disease .

C-mannosylation is the only known C-glycosylation. The C-mannosyltransferase α-mannose is attached to tryptophan in a Trp-x-xTrp sequence.

Individual evidence

  1. ↑ Mark Lommel, Sabine Strahl: Protein O-mannosylation is vital! BIOspektrum, accessed on July 4, 2020 .
  2. ↑ Yoshito Ihara, Yoko Inai, Midori Ikezaki, In-Sook L. Matsui, Shino Manabe: C-Mannosylation: A Modification on Tryptophan in Cellular Proteins . In: Glycoscience: Biology and Medicine . Springer Japan, Tokyo 2014, ISBN 978-4-431-54836-2 , pp. 1–8 , doi : 10.1007 / 978-4-431-54836-2_67-1 ( springer.com [accessed July 4, 2020]).