Margo Chene Pretorius gained her first international experience at the Junior African Championships 2013 in Réduit , where she won the silver medal with 49.66 m. In 2016 she finished ninth with 50.46 m at the African Championships in Durban, Germany, and in 2018 she finished sixth at the African Championships in Asaba with 58.86 m. The following year, she took part in the Africa Games in Rabat for the first time , where she finished seventh with a width of 60.30 m.
In 2015, 2018 and 2019 , Pretorius was the South African hammer throw champion.