Marine-Lenhart Syndrome

Classification according to ICD-10
E05.0	Hyperthyroidism with diffuse goiter - Graves' disease
ICD-10 online (WHO version 2019)

As Navy Lenhart syndrome , the simultaneous occurrence of a is nodular , with or without autonomy and of an immunogenic hyperthyroidism ( Graves' disease hereinafter).

The surgeons David Marine and Carl H. Lenhart , who worked in Cleveland , were the first to describe them in 1911. In the corresponding paper they presented their observations regarding the histopathology and iodine content of goiter . Among them were eight cases in which they had considered the simultaneous occurrence of a goiter and an adenoma to be coincidental.

The simultaneous occurrence of both causes of hyperfunction is rare and can make diagnosis difficult. The incidence of Marine-Lenhart syndrome is given as 1% for patients with Graves' disease.

Treatment is either surgical removal of the thyroid gland or radioiodine therapy . Therapy with anti-thyroid drugs may, however , be necessary for a limited time to produce euthyroidism .

The rare side effect of the additional occurrence of immunogenic hyperthyroidism a few weeks after radioiodine therapy due to thyroid autonomy (for example, autonomic adenoma ) is called Marine-Lenhart syndrome. This form of hyperfunction is mostly self-limiting; its frequency is given as 0.5 to 1%. In some of the cases, however, a second radioiodine therapy must be carried out because of the newly developed hyperthyroidism.

Individual evidence

1. ^ Frank Grünwald and Karl-Michael Derwahl: Diagnosis and therapy of thyroid diseases. Frankfurt, Berlin 2014 ISBN 978-3-86541-538-7 p. 33, p. 58, p. 84 and p. 111
2. ↑ DN Charkes: GRAVES 'DISEASE WITH FUNCTIONING NODULES (MARINE-LENHART SYNDROME).  ( Page no longer available , search in web archives )  Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice. In: JOURNAL OF NUCLEAR MEDICINE. Volume 13, Number 12, pp. 885-892.  
3. ^ D. Marine, CH Lenhart: Pathological anatomy of exophthalmic goiter. In: Arch Intern Med (Chicago). 1911; 8, pp. 265-316.
4. ↑ A. Schuler, C. Schreck, G. Becker, V. Herzau: Marine-Lenhart Syndrome: rare differential diagnosis in hyperthyroidism and endocrine orbitopathy. In: Ultrasound in Medicine - European Journal of Ultrasound. 25, 2004, doi : 10.1055 / s-2004-834258 .
5. ↑ P.-M Schumm-Draeger, O.-A Müller: Hyperthyroidism - The concrete case. In: DMW - German Medical Weekly. 128, 2003, p. 495, doi : 10.1055 / s-2003-37621 .
6. ↑ K. Mann, R. Hörmann: Antithyroid and TSH-suppressive treatment in Graves' disease? In: The internist. Springer Verlag, 1998; (39) 6: 600-612. (on-line)
7. ↑ F. Grünwald, C. Menzel. Radioiodine therapy. In: T. Kuwert, F. Grünwald , U. Haberkorn , T. Krause: Nuclear medicine. Stuttgart, New York 2008, ISBN 978-3-13-118504-4 .

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !