Martin Klingenspor

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Martin Klingenspor (born December 3, 1961 ) is a German zoologist, animal physiologist and nutritionist. He is Professor of Molecular Nutritional Medicine at the Technical University of Munich (Else Kröner Fresenius Endowed Professorship).

Life

Klingenspor studied biology at the Philipps University of Marburg from 1981, graduating in 1987. There he received his doctorate in animal physiology summa cum laude under Gerhard Heldmaier in 1994 and was a post-doctoral student in Marburg and at the Lipid Research Laboratory of the West Los Angeles Veterans Association Medical Center (1995/96) with Karen Reue . From 1997 he was back in Marburg, where he qualified as a professor in 2001 and took on a substitute professorship for animal physiology in 2004. In 2007 he became a professor at the Technical University of Munich.

He deals with the physiology of the regulation of the energy balance in the body, adaptation of the metabolism to different environmental conditions, metabolic disorders in mice and the metabolic effects of secondary plant substances . He is particularly interested in the metabolic mechanisms of overweight and their regulation down to the molecular biological level. For example, he used knockout mice to investigate the role of uncoupling protein (UCP) from the mitochondria in lipid metabolism and the role of neuronal messengers (such as melanocyte-stimulating hormone , leptin ). He also showed the role of post-transcriptional processes in the seasonal control of body weight in hamsters. Together with colleagues, he demonstrated the presence of UCP 1, which is used to build up fat stores, in pouch mice, which indicates a very early evolutionary origin (150 million years ago) and thus an important advantage in early mammals via a thermogenesis mechanism that is independent of muscle tremors of environmental adaptation.

He has been on the editorial board of Obesity Facts since 2008 and co-editor of the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology since 2007 . He is a member of the International Hibernation Society, the German Zoological Society , the German Obesity Society and the American Physiological Society (2005).

Fonts (selection)

  • M Klingenspor, H Niggemann, G Heldmaier: Modulation of leptin sensitivity by short photoperiod acclimation in the Djungarian hamster, Phodopus sungorus. In: Journal of Comparative Physiology B , 2000, 170 (1), pp. 37-43
  • with Gerhard Heldmaier (Ed.): Life in the Cold . Springer Verlag, 2003
  • M Jastroch, S Stöhr, K Withers, M Klingenspor: A quest for the origin of mammalian uncoupling proteins . In: Life in the Cold: Evolution, Mechanisms, Adaptation, and Application. 12th International Hibernation Symposium. Biological Papers of the University of Alaska No. 27, 2004, pp. 417-426
  • M Helwig, RM Khorooshi, A Tups, P Barrett, ZA Archer, C Exner, J Rozman, LJ Braulke, JG Mercer, M Klingenspor: PC1 / 3 and PC2 gene expression and post-translational endoproteolytic pro-opiomelanocortin processing is regulated by photoperiod in the seasonal Siberian hamster (Phodopus sungorus). In: J Neuroendocrinol . 2006; 18 (6), pp. 413-425, PMID 16684131 .
  • G Haemmerle, A Lass, R Zimmermann, G Gorkiewicz, C Meyer, J Rozman: Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase . In: Science , 2006, 312 (5774), pp. 734-737
  • M Jastroch, KW Withers, S Taudien, PB Frappell, M Helwig, T Fromme, V Hirschberg, G Heldmaier, BM McAllan, BT Firth, T Burmester, M Platzer, M Klingenspor: Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis. In: Physiol Genomics . 2008, 32 (2), pp. 161-169, PMID 17971503 .
  • T Fromme, C Hoffmann, K Nau, J Rozman, K Reichwald, M Utting, M Platzer, M Klingenspor: An intronic single base exchange leads to a brown adipose tissue specific loss of Ucp3 expression and an altered body mass trajectory. In: Physiol Genomics . 2009; 38 (1), pp. 54-62, PMID 19383623 .
  • F Bolze, M Klingenspor: Mouse models for the central melanocortin system. In: Genes Nutr . 2009, 4 (2), pp. 129-134, PMID 19266227 .
  • CW Meyer, M Willershäuser, M Jastroch, B Rourke, T Fromme, R Oelkrug, G Heldmaier, M Klingenspor: Adaptive thermogenesis and thermal conductance in wildtype and UCP1-KO mice. In: Am J Physiol Regul Integr Comp Physiol . 2010, 299 (5), pp. R1396-1406, PMID 20826705 .
  • Alexandros Vegiopoulos, Karin Müller-Decker, Daniela Strzoda, Iris Schmitt, Evgeny Chichelnitskiy, Anke Ostertag, Mauricio Berriel Diaz, Jan Rozman, Martin Hrabe de Angelis, Rolf M Nüsing, Carola W Meyer, Walter Wahli, Martin Klingenspor, Stephan Herzig: Cyclooxygenase -2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes . In: Science , 2010, 328 (5982), pp. 1158-1161

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personal data
SURNAME Klingenspor, Martin
BRIEF DESCRIPTION German zoologist, animal physiologist and nutritionist
DATE OF BIRTH 3rd December 1961