Melanocortin-3 receptor
| Melanocortin-3 receptor | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 360 amino acids | |
| Secondary to quaternary structure | multipass receptor | |
| Identifier | ||
| Gene name | MC3R | |
| External IDs | ||
The melanocortin receptor 3 (short: MC3R ) belongs to the group of melanocortin receptors and is a G-protein-coupled receptor . It is expressed in the brain (especially in regions of the hypothalamus near the organum vasculosum laminae terminalis ), the placenta , the intestinal tissue but not in the adrenal cortex or in melanocytes. It is activated by α-MSH , β-MSH , γ-MSH and by ACTH and is involved in vegetative regulation of energy homeostasis such as suppressing the fever reaction or influencing food utilization with reduced body fat accumulation and counter-regulation against the metabolic syndrome (see OMIM).
genetics
The MC3R is encoded on the chromosome segment 20q13.2-q13.3 and contains 360 amino acids .