Microcornea

Classification according to ICD-10
Q13.4	Microcornea, congenital
ICD-10 online (WHO version 2019)

A microcornea (from the Greek  μικρός mikros “small”) is a cornea that is too small, i.e. less than 10 mm in diameter in adults and less than 8 mm in newborns.

A microcornea is found in microphthalmia (eyes that are too small), other developmental disorders of the eye, and myopia in ametropia . Often only one eye is affected.

It can be part of a retinopathia prematurorum . and other syndromes such as Lenz syndrome , micro syndrome or geroderma osteodysplastica occur and is a key symptom in the following syndromes:

• Juvenile cataract - microcornea - renal glucosuria , based on mutations in the SLC16A12 gene at location 10q23.31
• CCMCO syndrome (cataract, congenital - microcornea - corneal opacity), autosomal - recessive , mutations in the PXDN gene at location 2p25.3
• Cataract Microcornea Syndrome
• MACOM syndrome
• MRCS syndrome (microcornea - cone-rod dystrophy - cataract - posterior staphyloma), autosomal dominant inheritance , mutations in the PXDN gene at location 2p25.3
• Microcornea - glaucoma - missing frontal sinuses
• Microcornea - Corctopia - Macular Hypoplasia
• MPCC Syndrome (Microcornea - Lenticonus Posterior - Persistent Hyperplastic Primary Vitreus - Coloboma)
• MMCAT syndrome (microcornea-myopic chorioretinal atrophy-telekanthus syndrome), autosomal - recessive , mutations in the ADAMTS18 gene at location 16q23.1
• Seemanova-Lesny syndrome (microcephaly-microcornea syndrome, Seemanova type)

Individual evidence

1. ↑ Z. Sohajda, D. Holló, A. Berta, L. Módis: Microcornea associated with myopia. In: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes archive for clinical and experimental ophthalmology. Vol. 244, No. 9, September 2006, pp. 1211-1213, doi: 10.1007 / s00417-006-0264-z , PMID 16496171 .
2. ^ SP Kelly, AR Fielder: Microcornea associated with retinopathy of prematurity. In: The British journal of ophthalmology. Vol. 71, No. 3, March 1987, pp. 201-203, PMID 3828276 , PMC 1041119 (free full text)
3. ↑ Cataract, juvenile, with microcornea and glucosuria.  In: Online Mendelian Inheritance in Man . (English)
4. ↑ Juvenile cataract - microcornea - renal glucosuria. In: Orphanet (Rare Disease Database).
5. ↑ Corneal opacification and other ocular anomalies.  In: Online Mendelian Inheritance in Man . (English)
6. ↑ Congenital cataract - microcornea - corneal opacity. In: Orphanet (Rare Disease Database).
7. ↑ Cataract Microcornea Syndrome. In: Orphanet (Rare Disease Database).
8. ↑ Colobomatous macrophthalmia-microcorneal syndrome. In: Orphanet (Rare Disease Database).
9. ↑ Microcornea, rod-cone dystrophy, cataract, and posterior staphyloma.  In: Online Mendelian Inheritance in Man . (English)
10. ↑ Microcornea - cone-rod dystrophy - cataract - posterior staphyloma. In: Orphanet (Rare Disease Database).
11. ↑ Microcornea - glaucoma - missing frontal sinuses. In: Orphanet (Rare Disease Database).
12. ↑ Microcornea - Corctopia - Macular Hypoplasia. In: Orphanet (Rare Disease Database).
13. ↑ Microcornea - Lenticonus posterior - persistent primary vitreus - coloboma. In: Orphanet (Rare Disease Database).
14. ↑ Microcornea, myopic chorioretinal atrophy, and telecanthus.  In: Online Mendelian Inheritance in Man . (English)
15. ↑ Microcorneal myopic chorioretinal atrophy-Telekanthus syndrome. In: Orphanet (Rare Disease Database).
16. ↑ Microcephaly-microcornea syndrome, Seemanova type. In: Orphanet (Rare Disease Database).

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !