Mitosis-promoting factor
The mitosis-promoting factor (also maturation promoting factor , M-phase promoting factor , abbreviated MPF ) is a protein complex , i.e. H. a network of proteins that is important for regulating the cell cycle in eukaryotes as it initiates mitosis . It consists of the cyclin-dependent kinase CDK1 (also called cdc2) and one of the regulatory proteins cyclin A or B.
When the two enzymes are inactive, CDK1 is phosphorylated and cyclin is dephosphorylated. After the CdK1 has been converted into a dephosphorylated form and the cyclin into a phosphorylated form, the two components combine to form the active mitosis-promoting factor. Through the kinase activity of CDK1, the MPF controls the phosphorylation of various proteins , such as histone H1 or Lamin, and thus initiates the prophase of mitosis. The activated proteins cause, among other things, a condensation of the chromatin , the dissolution of the nuclear envelope , through the phosphorylation of lamin B, and the organization of theSpindle apparatus . All of these processes are essential for mitosis.
Individual evidence
- ^ A b Scott F. Gilbert: Developmental Biology . 8th edition, Sinauer Associates, Sunderland, USA, 2006, ISBN 9780878932504 , p. 212
- ↑ Jan Koolman, Klaus-Heinrich Röhm, Jürgen Wirth: Pocket Atlas of Biochemistry. 3rd edition, Georg Thieme Verlag, 2002, ISBN 9783137594031 , p. 394