Neonator hemorrhagic disease

Classification according to ICD-10
P53	Haemorrhagic disease of the fetus and newborns
ICD-10 online (WHO version 2019)

The haemorrhagic disease of the newborn is in the newborn occurring bleeding due to a vitamin K deficiency .

It is a bleeding tendency that usually occurs within the first two to seven days of a child's life and can lead to bleeding in the skin, mucous membranes, scalp, navel or brain. Children who have not received vitamin K prophylaxis are almost always affected. The late manifestation of the M. haemorrhagicus neonatorum in the 3rd – 7th Week leads to life-threatening CNS bleeding in 50% of cases with a lethality of 20%. Due to the mother's relatively low vitamin K levels (especially if she is taking anticonvulsant medication, for example ), the immaturity of the liver and the scarcely existing intestinal flora in the child, there is a physiological vitamin K deficiency at this age, especially in breastfed infants. In the laboratory there is an increase in the partial thromboplastin time (PTT), thrombin time and bleeding time as well as a decrease in factors II, VII, IX and X.

Therefore all healthy newborns receive prophylactic vitamin K, see Sect. c. , i. m. or (in Germany) p. o. Vitamin K prophylaxis usually takes place in the context of U1, U2 and U3. If there is a risk that enteral absorption might not be sufficient, the application should be subcutaneous or intramuscular.

The assumption that vitamin K given parenterally has a carcinogenic effect has now been refuted.

Individual evidence

1. ↑ ^{a b} Ania Muntau (Ed.): Intensive Course in Pediatrics, with 130 tables . 5th, completely revised. and updated edition. Elsevier, Urban & Fischer, Munich 2009, ISBN 978-3-437-43392-4 .
2. ↑ RM Puckett, M. Offringa: Prophylactic vitamin K for vitamin K deficiency bleeding in neonates. In: Cochrane Database Syst Rev. 2000; (4), S. CD002776. PMID 11034761 , doi: 10.1002 / 14651858.CD002776 .
3. ^ SJ Passmore, G. Draper, P. Brownbill, M. Kroll: Case-control studies of relation between childhood cancer and neonatal vitamin K administration. In: BMJ. 1998 Jan 17; 316 (7126), pp. 178-184. PMID 9468681 .
4. ↑ MA Klebanoff, JS Read, JL Mills, PH Shiono: The risk of childhood cancer after neonatal exposure to vitamin K. In: N Engl J Med. 1993 Sep 23; 329 (13), pp 905-908. PMID 8361503 .
5. ^ JA Ross, SM Davies: Vitamin K prophylaxis and childhood cancer. In: Med Pediatr Oncol. 2000 Jun; 34 (6), pp. 434-437. PMID 10842253 , doi : 10.1002 / (SICI) 1096-911X (200006) 34: 6 <434 :: AID-MPO11> 3.0.CO; 2-X

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !