Multiple organ failure

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Multi organ failure ( MODS from English multi organ dysfunction syndrome or MOF from English multi organ failure ) refers to the simultaneous or sequential failure or severe functional impairment of various vital organ systems in the body .

The term MOV is now considered obsolete in specialist circles and has been replaced by MODS.

root cause

MODS can be the result of a number of pathological changes in the body. MODS often occurs in sepsis , in polytrauma patients or in decompensated internal diseases such as heart failure or as a result of a pronounced allergic reaction ( anaphylactic shock ).

Multiple organ failure can also occur with hereditary transaldolase deficiency.

The following organ systems can be affected:


Treatment of MODS is usually associated with admission to an intensive care unit , as this is a life-threatening condition. In intensive care medicine there are procedures to support the function of failed organs or to replace them completely (e.g. ventilation , dialysis , circulatory support through medication), but MODS is associated with a very high mortality rate .

Individual evidence

  1. Vassili Valayannopoulos, Nanda M. Verhoeven, Karine Mention, Gajja S. Salomons, Danièle Sommelet, Marie Gonzales, Guy Touati, Pascale de Lonlay, Cornelis Jakobs, Jean-Marie Saudubray: Transaldolase deficiency: a new cause of hydrops fetalis and neonatal multi -organ disease. In: The Journal of Pediatrics . Volume 149, No. 5, 2006, pp. 713-717, doi : 10.1016 / j.jpeds.2006.08.016 .