Myasthenia

A myasthenia (from ancient Greek μυς mys "muscle" and ἀσθένεια astheneia "weakness") or muscle weakness is a symptom of various diseases, comprising a load-dependent abnormally rapid fatigue and weakening of muscles describes.

One possible cause is myasthenia gravis or, more generally, myasthenic syndrome, which, in addition to myasthenia gravis, includes Lambert-Eaton-Rooke syndrome , neonatal myasthenia and congenital myasthenic syndrome .

Other possible causes of muscle weakness or paralysis can also be, for example, the following disorders:

Adverse drug effects are also a potential cause. Fluoroquinolone antibiotics can cause severe myasthenia after just a short ingestion. The muscle-damaging mechanism of fluoroquinolones is based on an inhibition of neuromuscular transmission and is linked to an intramuscular increase in lactate, disorders of the mitochondrial energy metabolism and increased intracellular calcium concentrations . Inhibition of RYR1 or sarcoplasmic Ca ²⁺ -ATPase ( SERCA ) by the covalently bound fluorine atom is assumed to be a possible cause of the disturbed calcium homeostasis .

Individual evidence

↑ Andrew Engel: Myasthenia Gravis and Myasthenic Disorders. Oxford University Press, New York 2012, ISBN 978-0-19-973867-0 , pp. 156-173
↑ Beatrice Alexandra Golomb, Hayley Jean Koslik, Alan J Redd: Fluoroquinolone-induced serious, persistent, multisymptom adverse effects . Ed .: BMJ Case Rep. Doi : 10.1136 / bcr-2015-209821 , PMC 4600819 (free full text).
↑ Silke Heldwein, Edeltraut Garbe, M Zeitz, Thomas Schneider, R Somasundaram: Ciprofloxacin-related acute severe myalgia necessitating emergency care treatment: A case report and review of the literature . tape 47 , April 1, 2009 ( researchgate.net [accessed June 22, 2018]).
↑ Permanent nerve damage from fluoroquinolones. In: Ärzteblatt. Retrieved October 11, 2018 .
↑ FDA Drug Safety Communication: FDA updates warnings for oral and injectable fluoroquinolone antibiotics due to disabling side effects. In: FDA. May 12, 2016. Retrieved October 11, 2018 .
↑ JP Sieb: Fluoroquinolone antibiotics block neuromuscular transmission . In: Neurology . tape 50 , no. 3 , March 1998, ISSN 0028-3878 , p. 804-807 , PMID 9521283 .
↑ ^a ^b Thomas Metterlein, Frank Schuster, Martin Hager, Norbert Roewer, Martin Anetseder: Metabolic effects as a cause of myotoxic effects of fluoroquinolones . In: Indian Journal of Pharmacology . tape 47 , no. 6 , November 1, 2015 ( ijp-online.com [accessed June 22, 2018]).

[1] Andrew Engel: Myasthenia Gravis and Myasthenic Disorders. Oxford University Press, New York 2012, ISBN 978-0-19-973867-0 , pp. 156-173

[2] Beatrice Alexandra Golomb, Hayley Jean Koslik, Alan J Redd: Fluoroquinolone-induced serious, persistent, multisymptom adverse effects . Ed .: BMJ Case Rep. Doi : 10.1136 / bcr-2015-209821 , PMC 4600819 (free full text).

[3] Silke Heldwein, Edeltraut Garbe, M Zeitz, Thomas Schneider, R Somasundaram: Ciprofloxacin-related acute severe myalgia necessitating emergency care treatment: A case report and review of the literature . tape 47 , April 1, 2009 ( researchgate.net [accessed June 22, 2018]).

[4] Permanent nerve damage from fluoroquinolones. In: Ärzteblatt. Retrieved October 11, 2018 .

[5] FDA Drug Safety Communication: FDA updates warnings for oral and injectable fluoroquinolone antibiotics due to disabling side effects. In: FDA. May 12, 2016. Retrieved October 11, 2018 .

[6] JP Sieb: Fluoroquinolone antibiotics block neuromuscular transmission . In: Neurology . tape 50 , no. 3 , March 1998, ISSN 0028-3878 , p. 804-807 , PMID 9521283 .

[:8-7] Thomas Metterlein, Frank Schuster, Martin Hager, Norbert Roewer, Martin Anetseder: Metabolic effects as a cause of myotoxic effects of fluoroquinolones . In: Indian Journal of Pharmacology . tape 47 , no. 6 , November 1, 2015 ( ijp-online.com [accessed June 22, 2018]).