Myogenin
| Myogenin | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 224 amino acids | |
| Secondary to quaternary structure | Heterodimer with HLH protein | |
| Identifier | ||
| Gene name | MYOG | |
| External IDs | ||
| Occurrence | ||
| Homology family | Myogenic factors | |
| Parent taxon | Vertebrates | |
Myogenin is a transcription factor in vertebrates that is involved in activating muscle-specific genes . In particular, myogenin occurs during regeneration phases in skeletal muscles and plays a role in the formation of skeletal muscle fibers during certain stages of embryonic development .
The name Myf-4 is also used in connection with the human genome . If high concentrations of myogenin are present, it mainly binds as a homodimer to its characteristic binding sequences in the promoter of the regulated genes. In low concentrations it forms heterodimers together with other transcription factors, which in turn bind to the DNA . Possible cooperating transcription factors are MEF-2, NF-1, E12 and COMP1.
See also
Individual evidence
- ↑ YN Jang, EJ Baik: JAK-STAT pathway and myogenic differentiation. In: JAK-STAT. Volume 2, number 2, April 2013, p. E23282, ISSN 2162-3988 . doi : 10.4161 / jkst.23282 . PMID 24058805 . PMC 3710318 (free full text).
- ↑ K. Singh, FJ Dilworth: Differential modulation of cell cycle progression distinguishes members of the myogenic regulatory factor family of transcription factors. In: The FEBS journal. Volume 280, Number 17, September 2013, pp. 3991-4003, ISSN 1742-4658 . doi : 10.1111 / febs.12188 . PMID 23419170 .