NaSSA

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NaSSA is the abbreviation for English noradrenergic and Specific Serotonergic Antidepressant ( dt .: noradrenergic and specific serotonergic antidepressant), a group of antidepressant psychotropic drugs . They are among the so-called "newer antidepressants".

These tetracyclic active ingredients bind to binding sites ( receptors ) for the monoamines noradrenaline and serotonin , which normally act as a feedback to inhibit the release of these transmitters at the nerve endings. The concentration of the transmitters increases under the influence of NaSSA. In this respect , the effect of NaSSA is similar to that of SSNRI antidepressants ( selective serotonin and norepinephrine reuptake inhibitors ). However, they have a significantly stronger antihistaminergic and therefore sedating effect.

NaSSA are antagonists of presynaptic auto-receptors of the alpha-2 adrenoceptor type and thus cause an increased release of noradrenaline. In addition, they are antagonists of specific serotonin receptors, usually 5-HT 2A and 5-HT 2C , but also 5-HT 1F , or 5-HT 2B, depending on the NaSSA active ingredient. Mirtazapine presumably acts as an agonist on the serotonin autoreceptors of the type 5-HT 1A and thus prevents an increase in serotonergic transmission mediated by α 2A / C blockade. Usually NaSSA act as H1 antihistamines as sedating.

The first NaSSA mianserin was patented by Organon ( Tolvin ® ) in 1967 and is commercially available as a generic. Other NaSSAs are mirtazapine and the setiptiline used in Japan , both of which are chemically closely related to mianserine.

Individual evidence

  1. ^ A b Robert M. Julien: A Primer Of Drug Action: A Comprehensive Guide To The Actions, Uses, And Side Effects Of Psychoactive Drugs . Macmillan, September 17, 2004, ISBN 978-0-7167-0615-1 , p. 286 (Retrieved April 23, 2012).
  2. ↑ Roth, BL; Driscol, J: PDSP K i Database . In: Psychoactive Drug Screening Program (PDSP) . University of North Carolina at Chapel Hill and the United States National Institute of Mental Health. January 12, 2011. Archived from the original on November 8, 2013. Info: The archive link was automatically inserted and not yet checked. Please check the original and archive link according to the instructions and then remove this notice. Retrieved October 13, 2013. @1@ 2Template: Webachiv / IABot / pdsp.med.unc.edu
  3. ↑ K. Fukuyama et al .: Differential mechanisms underlie the regulation of serotonergic transmission in the dorsal and median raphe nuclei by mirtazapine: a dual probe microdialysis study. . In: Psychopharmacology . 229, No. 4, 2013, pp. 617-626. doi : 10.1007 / s00213-013-3122-9 . PMID 23657423 .
  4. ↑ Entry on Mianserin. In: Römpp Online . Georg Thieme Verlag, accessed April 1, 2014.