Neural cell adhesion molecule 1

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Neural cell adhesion molecule 1
Neural cell adhesion molecule 1
other names

CD56, MSK39, NCAM1

Existing structural data : PDB  2E3V , PDB  2HAZ , PDB  2VKW

Properties of human protein
Mass / length primary structure 858 amino acids , 94,574 Da
Identifier
External IDs

The neural cell adhesion molecule 1 (NCAM1), also CD56, is a surface protein from the group of cell adhesion molecules .

properties

NCAM1 mediates cell contact between neurons and is a cell adhesion molecule on the pre- and postsynaptic membrane. It is involved in the formation of neurites and in the learning process. NCAM1 is glycosylated and phosphorylated with polysialic acids . NCAM1 belongs to the immunoglobulin superfamily with five immunoglobulin - protein domains to bind to NCAM on top of each other synaptic membrane and two fibronectin domains of type III, associated with neurite outgrowth. The sialylation is essential for binding to other NCAM. At least 27 alternatively spliced mRNA are produced by NCAM in the brain of rats . The three most important isoforms of NCAM1 are a variant with a GPI anchor but without a transmembrane domain of around 120 kDa and two isoforms with a transmembrane domain of around 140 and 180 kDa (kilodaltons) .

NCAM1 is the cellular receptor of the rabies virus for binding to the cell surface.

Web links

Individual evidence

  1. ↑ X. Yang, D. Hou, W. Jiang, C. Zhang: Intercellular protein-protein interactions at synapses. In: Protein & cell. Volume 5, number 6, June 2014, pp. 420–444, doi : 10.1007 / s13238-014-0054-z , PMID 24756565 , PMC 4026422 (free full text).
  2. ^ AA Reyes, SJ Small, R. Akeson: At least 27 alternatively spliced ​​forms of the neural cell adhesion molecule mRNA are expressed during rat heart development. In: Molecular and cellular biology. Volume 11, Number 3, March 1991, pp. 1654-1661, PMID 1996115 , PMC 369464 (free full text).
  3. ↑ M. Suzuki, K. Angata, J. Nakayama, M. Fukuda: Polysialic acid and mucin type o-glycans on the neural cell adhesion molecule differentially regulate myoblast fusion. In: The Journal of biological chemistry. Volume 278, Number 49, December 2003, pp. 49459-49468, doi : 10.1074 / jbc.M308316200 , PMID 13679364 .