Nirvanin
Structural formula | |||||||||||||
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Non-proprietary name | Nirvanin | ||||||||||||
other names |
5- (Diethylaminoacetamido) salicylic acid methyl ester |
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Molecular formula | C 14 H 20 N 2 O 4 | ||||||||||||
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properties | |||||||||||||
Molar mass | 280.32 g mol −1 | ||||||||||||
safety instructions | |||||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Nirvanin is the name of the first local anesthetic from the aminoamide group.
It was first synthesized by Alfred Einhorn and in 1898 by the Farbwerke vorm. Meister Lucius & Brüning AG introduced into the trade. Because of its local irritant effect and low penetration compared to the reference substance cocaine , it had to be taken off the market again. It was not until 1943 that Nils Löfgren synthesized lidocaine , which is still used in medicine today and is usually referred to as the first aminoamide , which became the starting substance for the development of other local anesthetics from the aminoamide group.
Individual evidence
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ^ Charles Owens Wilson: Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry. Lippincott Williams & Wilkins, 2004, ISBN 978-0-781-73481-3 , p. 677 ( limited preview in Google book search).
- ↑ Richard Liebenherr: Synthesis of some local anesthetic and tuberculostatic derivatives of 2-oxy-4-aminoquinoline , dissertation, ETH Zurich, 1950.