Nirvanin

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Structural formula
Nirvanine.svg
General
Non-proprietary name Nirvanin
other names

5- (Diethylaminoacetamido) salicylic acid methyl ester

Molecular formula C 14 H 20 N 2 O 4
External identifiers / databases
CAS number 6245-02-9
PubChem 3083948
ChemSpider 2341085
Wikidata Q1540477
properties
Molar mass 280.32 g mol −1
safety instructions
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Nirvanin is the name of the first local anesthetic from the aminoamide group.

It was first synthesized by Alfred Einhorn and in 1898 by the Farbwerke vorm. Meister Lucius & Brüning AG introduced into the trade. Because of its local irritant effect and low penetration compared to the reference substance cocaine , it had to be taken off the market again. It was not until 1943 that Nils Löfgren synthesized lidocaine , which is still used in medicine today and is usually referred to as the first aminoamide , which became the starting substance for the development of other local anesthetics from the aminoamide group.

Individual evidence

  1. This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  2. ^ Charles Owens Wilson: Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry. Lippincott Williams & Wilkins, 2004, ISBN 978-0-781-73481-3 , p. 677 ( limited preview in Google book search).
  3. Richard Liebenherr: Synthesis of some local anesthetic and tuberculostatic derivatives of 2-oxy-4-aminoquinoline , dissertation, ETH Zurich, 1950.