Nucleoproteins

Nucleoproteins are proteins that bind to nucleic acids (DNA or RNA). Classic examples of nucleoproteins are the DNA-binding proteins such as the histones , the protamines , but also the ribonucleoproteins (e.g. the ribosome , the RNA-induced silencing complex or the telomerase ) or the nucleoprotein (NP) of the influenza virus . At the binding sites for the phosphate groups of the nucleic acids, the nucleoproteins often have basic amino acids for charge balancing and complexing, or acidic amino acids that can bind the cofactor Mg ²⁺ . The phosphate groups of the DNA can be bound indirectly via the Mg ²⁺ .

The term, nucleoproteins' (engl. Nucleoprotein ) is not with nuclear proteins (engl. Nuclear proteins ), proteins of the virus core within the viral envelope (engl. Core protein ) or to the protein backbone of a glycoprotein (engl. Core protein, protein core ) to be confused.

literature

• Jeremy M. Berg, John L. Tymoczko, Lubert Stryer: Stryer Biochemistry. 6th edition, Spektrum Akademischer Verlag, Munich 2007. ISBN 978-3-8274-1800-5 .
• DM Knipe, Peter M. Howley (Ed.): Fields Virology. 4th edition, Philadelphia 2001. ISBN 0-7817-6060-7 .

Web links

• MESH database, keyword nucleoproteins . Retrieved April 4, 2013.