Opsoclonus-Myoclonus Syndrome

Classification according to ICD-11
9C85.02	Inappropriate saccades
ICD-11 ( WHO version 2019)

The opsoclonus myoclonus syndrome (OMS) - also Kinsbourne syndrome and in the English language dancing eye-dancing feet-syndrome - is a disease that in the context of a paraneoplastic syndrome can occur as a side effect of various tumor diseases. The occurrence of neuroblastomas and medulloblastomas in children is described. In adults, it can be an indication of breast cancer or small cell bronchial carcinoma .

Neuroblastoma can be found in around half of children diagnosed with OMS. OMS is present in about 2-3% of neuroblastoma patients.

Children with OMS have irregular, uncontrolled movements of the eyes ( opsoclonus ) and limbs ( myoclonus ). It looks as if children who have an OMS and a neuroblastoma have a better chance of developing the tumor , but the OMS still has a long-term disability that requires intensive medical care and treatment.

The OMS may arise because the body often successfully defends itself against the tumor , but the antibodies that are created also damage the nervous system . So far there is hardly any information about this particular phenomenon of neuroblastoma.

Web links

Individual evidence

↑ R. Cooper, Y. Khakoo, KK Matthay, JN Lukens, RC Seeger, DO Stram, RB Gerbing, A. Nakagawa, H. Shimada: Opsoclonus-myoclonus-ataxia syndrome in neuroblastoma: histopathologic features-a report from the Children's Cancer Group . In: Med. Pediatr. Oncol. tape 36 , no. 6 , June 2001, p. 623-629 , doi : 10.1002 / mpo.1139 , PMID 11344493 .

[pmid11344493-1] R. Cooper, Y. Khakoo, KK Matthay, JN Lukens, RC Seeger, DO Stram, RB Gerbing, A. Nakagawa, H. Shimada: Opsoclonus-myoclonus-ataxia syndrome in neuroblastoma: histopathologic features-a report from the Children's Cancer Group . In: Med. Pediatr. Oncol. tape 36 , no. 6 , June 2001, p. 623-629 , doi : 10.1002 / mpo.1139 , PMID 11344493 .