Organ-on-a-Chip

An organ-on-chip is a biochip for simulating organs in a cell culture .

properties

An organ-on-a-chip is a multichannel 3-D microfluidic biochip that simulates the activities, mechanics and physiological reactions of entire organs and organ systems - a kind of artificial organ. The chip is mostly made from polydimethylsiloxane (PDMS).

See also

• Lab-on-a-Chip
• Organoid

literature

• EL Jackson, H. Lu: Three-dimensional models for studying development and disease: moving on from organisms to organs-on-a-chip and organoids . In: Integrative Biology . tape 8 , no. 6 , June 2016, p. 672-683 , doi : 10.1039 / c6ib00039h (English).

Web links

• Peter Buchmann: Living organs on a chip. Swiss radio and television , June 6, 2018 . 
• Corina Gericke, Julia Schulz: Organ chip technology on the advance. Doctors Against Animal Experiments e. V., May 28, 2018 (listing of organ simulations from various research institutions). 
• Attract Group Organ-on-a-Chip. Fraunhofer Institute for Interfacial Engineering and Bioprocess Engineering .
• European Organ-on-Chip Society starts work. International cooperation (initiative of the BMBF ), November 9, 2018. 
• Fraunhofer - A plug-and-play human. European Association of Research and Technology Organizations (third place in the “Impact Expected” category of the EARTO Innovation Awards 2018 for the multi-organchip from Fraunhofer IWS Dresden): “Organ-on-chip technology has been named one of the world's top 10 emerging technologies. The microphysiological system market is growing at an annual rate of over 60% and is predicted to be worth € 145 million by 2023. […] EARTO member Fraunhofer created the world's first fully customizable MOC [Multi-Organ-Chip] platform within a closed circulation system. [...] The platform is expected to help European companies secure 30% of the rapidly-growing MOC market over the next five years, equating to volume of more than € 50m a year. " 

Individual evidence

1. ↑ Melinda Wenner Moyer: Organs-on-a-Chip for Faster Drug Development , Scientific American , February 25, 2011
2. ↑ Sriram G, Alberti M, Dancik Y, Wu B, Wu R, Feng Z, Ramasamy S, Bigliardi PL, Bigliardi-Qi M, Wang Z: Full-thickness human skin-on-chip with enhanced epidermal morphogenesis and barrier function . In: Materials Today . 21, No. 4, May 2018, pp. 326-340. doi : 10.1016 / j.mattod.2017.11.002 .