POEM @ home
| POEM @ home | |
|---|---|
 |
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| Area: | biochemistry |
| Target: | Analysis and prediction of protein structure |
| Operator: | Karlsruher Institute for Technology |
| Country: | Germany |
| Platform: | BOINC |
| Website: | http://boinc.fzk.de/poem |
| Project status | |
| Status: | completed |
| Start: | October 2007 |
| The End: | October 2016 |
POEM @ home ( P rotein O ptimization with E nergy M ethods, Protein Optimization with Energy Methods) was a volunteer computing the project Karlsruhe Institute of Technology , which means the technique of distributed computing , tried protein structures to optimize.
To do this, it used an atomic model for the free energy of the proteins , so POEM @ home worked for both new protein folds and applications in nanobiotechnology for which no experimental data were available. The project started in October 2007. The basis of the calculations was the BOINC software from the University of California, Berkeley . In the end, the computing power of the project was around 739 TeraFLOPS , which could fluctuate depending on the daily performance.
Scientific relevance
A different scientific approach to protein folding was used than in similar projects. For this purpose, Christian B. Anfinsen's Nobel Prize-winning thermodynamic hypothesis was used, which states that proteins have minimal free energy in their biologically active state. The otherwise usual simulation processes, which are expensive in terms of computing time, have been replaced by much faster optimization processes.
After a short time POEM @ home was able to show the first results. With these results, the project also took part in the international research competition CASP , which takes place every two years .
aims
POEM @ home pursued the following goals:
- Prediction of the biologically active structure of proteins
- Understanding of the signal processing mechanisms during the interaction of different proteins
- Understanding of disease on the protein malfunction or - aggregations based
- Development of new drugs based on three-dimensional structures of biologically important proteins
See also
Individual evidence
- ↑ POEM @ home server status ( memento of the original from February 24, 2014 in the Internet Archive ) Info: The archive link was automatically inserted and not yet checked. Please check the original and archive link according to the instructions and then remove this notice.
- ↑ POEM forum ( Memento of the original dated December 6, 2007 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice.
- ↑ POEM @ home ( memento of the original dated January 6, 2008 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice.
