Patrick G. Holt
Patrick George Holt (born before 1981) is an Australian medical doctor ( pulmonology , pediatrics , allergology , immunology ), known for research on the immune system in the respiratory tract and the development of asthma in children.
Life
He is Professor at Telethon Kids Institute (formerly Telethon Institute of Child Health Research) in Perth , Australia, Founder (1990) and Director of the Cell Biology Department.
In 1981 he found that inhaled antigens can increase immunological tolerance.
He discovered and studied the role of dendritic cells (DC) in the respiratory immune system and their role in the activation of T cells in the development of chronic asthma. He is leading a clinical study for a treatment that aims to make children genetically predisposed to asthma more immune-tolerant through targeted oral exposure of antigens (such as house mites, grass, pet traces). He also found evidence of the role of infectious diseases (viruses) in atopic reactions in the airways. His research supported the thesis that the risk of developing asthma and allergies is determined by events during the maturation of the immune system in early childhood.
He studied the immunobiology of macrophages in the alveoli and developed the ELISPOT technique.
In 1999 he and Stephen T. Holgate received the Koenig Faisal Prize in Medicine especially for asthma research. Holt is a Fellow of the Royal College of Pathologists and the Australian Academy of Sciences (2001). In 2003 he received the Scientific Achievement Award from the World Allergy Association and in 1989 the Pharmacia Prize in Allergy.
Web links
Individual evidence
- ↑ Patrick G. Holt, Janet E. Batty, KJ Turner: Immunology , Vol. 42 (1981), pp. 409, ISSN 0019-2805 .
| personal data | |
|---|---|
| SURNAME | Holt, Patrick G. |
| ALTERNATIVE NAMES | Holt, Patrick George (full name) |
| BRIEF DESCRIPTION | Australian medic |
| DATE OF BIRTH | before 1981 |