Peptidyl transferase
The peptidyl transferase is the primary enzymatic function of the ribosome , which forms peptide bonds between amino acids with the help of tRNA during protein biosynthesis . Ribosomes are macromolecular complexes made up of proteins and ribonucleic acids . Since the catalytic function is carried out by the ribosomal ribonucleic acids and not by the ribosomal proteins, one speaks of a ribozyme .
The EC number was set to EC 2.3.2.12 . With PDB 2w1j there is at least one analyzed structure (from Streptococcus pneumoniae ). There are a variety of inhibitors.
- In bacteria , the 50S ribosome subunit contains peptidyl transferase.
- In eukaryotic cells , the 60S ribosome subunit contains peptidyl transferase.
literature
- Gu Z, Harrod R, Rogers EJ, Lovett PS: Anti-peptidyl transferase leader peptides of attenuation-regulated chloramphenicol resistance genes . In: Proc. Natl. Acad. Sci. USA . 91, No. 12, June 1994, pp. 5612-6. PMID 7515506 . PMC 44046 (free full text).
- Lovett PS, Rogers EJ: Ribosome regulation by the nascent peptide . In: Microbiol. Rev. . 60, No. 2, June 1996, pp. 366-85. PMID 8801438 . PMC 239448 (free full text).