Perchlorate Depletion Test

The perchlorate depletion test is a nuclear medicine test for detecting Pendred syndrome , a rare sensorineural hearing loss, and other iodine metabolism disorders.

In healthy people, after iodine is absorbed into the thyroid gland, oxidation takes place there with the help of the enzyme thyroid peroxidase . Since this enzyme is absent in Pendred's syndrome , iodide is present in the thyroid in an inorganic and freely diffusible form. By administering sodium perchlorate , this iodine can be competitively displaced ("depletion").

The perchlorate depletion test makes use of this relationship. The activity above the thyroid gland is determined by means of a gamma camera after first radioactive ¹²³ iodine (due to the significantly longer half-life and the released beta radiation and the associated higher radiation exposure , ¹³¹ iodine is no longer used) and some time later perchlorate. While radioactivity remains in the thyroid gland in healthy individuals, there is a rapid decline in activity in patients with Pendred's syndrome or another iodine utilization disorder.

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• K. Hahn, S. Fischer. The ¹²³ iodine depletion test for diagnosing Pendred syndrome in children. Nuclear Medicine 2009; 32: 17-18. doi : 10.1055 / s-0028-1119389
• Torsten Kuwert. Thyroid. in: Torsten Kuwert, Frank Grünwald , Uwe Haberkorn , Thomas Krause (Eds.) Nuclear Medicine. Stuttgart 2008 ISBN 978-3-13-118504-4

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