Peter K. Gregersen

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Peter K. Gregersen

Peter K. Gregersen (* 1950 ) is an American physician and geneticist, known for the genetics of autoimmune diseases and specifically rheumatoid arthritis , lupus erythematosus and myasthenia gravis .

life and work

Gregersen received his bachelor's degree in natural science from Johns Hopkins University in 1972 and then studied medicine at Columbia University (College of Physicians and Surgeons) with an MD degree in 1976. Initially he worked as a rheumatologist and then went into research on the genetics of rheumatic Diseases. He heads the Robert S. Boas Center for Genomics and Human Genetics at the Feinstein Institute for Medical Research in Manhasset near New York (North Shore University Hospital).

At the end of the 1980s, he and Robert J. Winchester identified genes that increase the risk of rheumatoid arthritis and code for certain HLA proteins that present the immune system on the cell surface with antigens from viruses when the virus decays, for example, whereupon the cell is attacked by the immune system. In the case of inherent risk of arthritis, the HLA proteins formed specially shaped complexes on the cell surface.

With his team, he identified a number of genes that influence the predisposition to rheumatoid arthritis and a number of genes that influence susceptibility to autoimmune diseases in general by regulating the level of activity of the immune system (CSK, TNIP 1, BLK, PTPN22 ).

In 2007 he received the Klemperer Medal from the New York Academy of Medicine and the Distinguished Basic Investigator Award from the American College of Rheumatology (ACR). In 2013 he received the Crafoord Prize with Lars Klareskog and Robert J. Winchester for polyarthritis research.

Fonts

  • with JH Cho Genomics and the multifactorial nature of human autoimmune disease . In: New England Journal of Medicine , Volume 365, Oct. 2011, pp. 1612-1623
  • with LM Olsson: Recent advances in the genetics of autoimmune disease . In: Annual Review Immunology , Volume 27, 2009, pp. 363-391.
  • with Winchester, J. Silver The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis . In: Arthritis & Rheumatism , 30, 1987, 1205-1213
  • with Winchester The molecular basis of susceptability to rheumatic arthritis: the conformational equivalence hypothesis , Springer Seminar Immunopathology, 10, 1988, 119-139

Web links

Individual evidence

  1. ^ Announcement by the Crafoord Foundation
personal data
SURNAME Gregersen, Peter K.
BRIEF DESCRIPTION American medic
DATE OF BIRTH 1950