Robert J. Winchester
Robert J. Winchester (born January 27, 1937 in Yonkers , New York ) is an American physician, known for researching the genetic predisposition of rheumatoid arthritis , lupus erythematosus and other autoimmune diseases .
Education and career
Winchester studied at Cornell University with an MD degree in 1963 and internship and residency at New York Hospital-Cornell Medical Center. He is a specialist in internal medicine and rheumatology. From 1960 to 1979 he was a professor at Rockefeller University where he worked closely with Henry G. Kunkel , who had a formative influence on him. From 1980 to 1986 he was a professor at the Mount Sinai School of Medicine . He is currently Professor of Pediatrics , Pathology and Medicine at Columbia University (Rheumatology Department).
plant
At the end of the 1980s, he and Peter K. Gregersen identified genes that increase the risk of rheumatoid arthritis and code for certain HLA proteins in the MHC complex that present the immune system on the cell surface, for example with antigens from viruses when the virus decays, whereupon the cell attacked by the immune system. With Gregersen he found that a special form of the MHC complexes, for which the gene variants code, is responsible for an increased susceptibility to the development of rheumatoid arthritis.
Awards and memberships
- 2007 Excellence in Investigative Mentoring Award from the American College of Rheumatology
- 2013 Crafoord Prize for Polyarthritis Research with Lars Klareskog and Gregersen
- 2017 Distinguished Basic Science Investigator Award from the American College of Rheumatology
He is a member of the American Association for the Advancement of Science .
Fonts (selection)
- with Gregersen, J. Silver The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis . In: Arthritis & Rheumatism , 30, 1987, 1205-1213
- with Gregersen The molecular basis of susceptibility to rheumatic arthritis: the conformational equivalence hypothesis , Springer Seminar Immunopathology, 10, 1988, 119-139
Web links
Individual evidence
- ↑ Life data according to American Men and Women of Science , Thomson Gale 2004
- ^ Announcement by the Crafoord Foundation
| personal data | |
|---|---|
| SURNAME | Winchester, Robert J. |
| BRIEF DESCRIPTION | American medic |
| DATE OF BIRTH | January 27, 1937 |
| PLACE OF BIRTH | Yonkers , New York |