Phospholipase A 2 receptor
| Phospholipase A 2 receptor | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 1443 amino acids | |
| Secondary to quaternary structure | single pass membrane receptor | |
| Isoforms | 2 | |
| Identifier | ||
| Gene name | PLA2R1 | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Vertebrates | |
Phospholipase A 2 receptor (PLA2R) is a type 1 transmembrane protein that binds several types of phospholipase A₂ . PLA2R is one of the four mannose receptors found in mammals . PLA2R is mainly used in human kidneys from the podocytes of renal corpuscle expressed . Although the exact physiological significance of the phospholipase A 2 receptor is not yet known, it is clear that the receptor, by binding to the respective phospholipase, participates in both the positive or negative regulation of its function and in its elimination. In general, PLA2R is able to bind lectins of the ricin type.
Medical importance
The formation of autoantibodies against PLA2R leads to membranous glomerulonephritis , a chronic kidney disease that is associated with high protein losses through the urine and increasing kidney function impairment .
literature
- ↑ Homologues at OMA
- ↑ UniProt Q13018
- ↑ Laurence H Beck, Ramon GB Bonegio, Gérard Lambeau, David M. Beck, David W. Powell, Timothy D. Cummins, Jon B. Klein, David J. Salant: M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy . In: The New England Journal of Medicine . 361, No. 1, July 2, 2009, pp. 11-21. doi : 10.1056 / NEJMoa0810457 . PMID 19571279 .
Web links
- The mannose receptors from RD Cummings, ME Etzler: R-type lectins. In: A. Varki: Essentials of Glycobiology. 2nd Edition.