|Properties of human protein|
|Mass / length primary structure||42,201 Daltons / 383 amino acids (Isoform1)
34,421 Daltons / 315 amino acids (Isoform2)
|Gene locus||Chr 1: 179.55 - 179.58 Mb||Chr 1: 156.31 - 156.33 Mb|
Podocin is a protein that is encoded by the NPHS2 gene . It plays a role in regulating glomerular permeability (permeability of the kidney) because it likely acts as a connecting protein between the plasma membrane and the cytoskeleton . In addition, it probably has a transmembrane domain and a C terminus that protrudes into the cytoplasm . These sections of the protein are largely homologous to the corresponding sections of stomatin , with which Podocin has the greatest homology.
Mutations in this gene lead to steroid-resistant nephrotic syndrome . Podocin was first discovered in 2000 in the course of research aimed at finding the causal gene for steroid-resistant nephrotic syndrome. It is only expressed in podocytes .