Polyoxines

Structural formula 1

Structural formula 2

Substituent X

Structural formula 3

The polyoxins are a group of nucleoside antibiotics . They are obtained from Streptomyces species such as Streptomyces cacaoi . Polyoxins are water-soluble and are used as fungicides in Japanese rice cultivation . They work by inhibiting chitin biosynthesis.

Surname	CAS number	Molecular formula	Molar mass [g · mol −1 ]	Melting point [° C]	See formula	R 1	R 2	R 3
Polyoxin A.	19396-03-3	C 23 H 32 N 6 O 14	616.54	amorphous	1	CH 2 OH	X	OH
Polyoxine B	19396-06-6	C 17 H 25 N 5 O 13	507.41	amorphous	1	CH 2 OH	OH	OH
Polyoxine D.	22976-86-9	C 17 H 23 N 5 O 14	521.39	> 190 (decomposes)	1	COOH	OH	OH
Polyoxine E.	22976-87-0	C 17 H 23 N 5 O 13	505.39	> 180 (decomposes)	1	COOH	OH	H
Polyoxin F	23116-76-9	C 23 H 30 N 6 O 15	630.52	> 190 (decomposes)	1	COOH	X	OH
Polyoxine G.	22976-88-1	C 17 H 25 N 5 O 12	491.41	> 190 (decomposes)	1	CH 2 OH	OH	H
Polyoxine H	24695-54-3	C 23 H 32 N 6 O 13	600.54	-	1	CH 3	X	OH
Polyoxine J.	22976-89-2	C 17 H 25 N 5 O 12	491.41	amorphous	1	CH 3	OH	OH
Polyoxine K	22886-46-0	C 22 H 30 N 6 O 13	586.51	amorphous	1	H	X	OH
Polyoxine L.	22976-90-5	C 16 H 23 N 5 O 12	477.38	amorphous	1	H	OH	OH
Polyoxine M.	34718-88-2	C 16 H 23 N 5 O 11	461.39	-	1	H	OH	H
Polyoxine C	21027-33-8	C 11 H 15 N 3 O 8	317.26	260-267	2	R = OH
Polyoxine I.	22886-33-5	C 17 H 22 N 4 O 9	426.38	amorphous	2	R = X
Polyoxine N	37362-29-1	C 16 H 23 N 5 O 12	477.38	190 (decomposes)	3	R = OH
Polyoxine O	37362-28-0	C 16 H 23 N 5 O 11	461.39	> 190 (decomposes)	3	R = H

• 

  Polyoxin A.

• 

  Polyoxine D.

literature

• Guoqing Niu, Huarong Tan: Nucleoside antibiotics: biosynthesis, regulation, and biotechnology . In: Trends in Microbiology . 2014. doi : 10.1016 / j.tim.2014.10.007 .

Individual evidence

1. ↑ Entry on polyoxins. In: Römpp Online . Georg Thieme Verlag, accessed on January 18, 2015.