Nucleoside antibiotics

Polyoxine D.

Puromycin

The nucleoside antibiotics are a group of antibiotics which are derived from nucleosides . They are not used in human medicine.

The nucleoside antibiotics have a similar structure, but differ in their mechanisms of action. The antibacterial nucleoside antibiotics inhibit the biosynthesis of the cell wall by inhibiting the bacterial translocase I (MraY). The fungicidal nucleoside antibiotics also act on the cell wall, but they inhibit chitin synthase . The antiviral nucleoside antibiotics block peptidyl transferase .

Classification

Antibacterial ( uridine ) antibiotics

• Uridyl peptide antibiotics
  • Pacidamycin
  • Napsamycin
  • Mureidomycin
  • Sansanmycin

• Uridyl lipopeptide antibiotics
  • Liposidomycin
  • Caprazamycin
  • Muraymycin
  • Muraminomicin

• Uridyl lipodisaccharide antibiotics
  • Tunicamycin

• Uridyl glycosyl peptide antibiotics
  • Capuramycin

Fungicidal nucleoside antibiotics

• Nikkomycin
• Polyoxines
• Blasticidin S.
• Arginomycin
• Mildiomycin

Antiviral nucleoside antibiotics

• Puromycin (derived from adenosine)

literature

• Michael Winn, Rebecca JM Goss, Ken-ichi Kimura, Timothy DH Bugg: Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure – function studies and nucleoside biosynthesis . In: Natural Product Reports . tape 27 , no. 2 , 2010, p. 279 , doi : 10.1039 / b816215h .
• Guoqing Niu, Huarong Tan: Nucleoside antibiotics: biosynthesis, regulation, and biotechnology . In: Trends in Microbiology . 2014, doi : 10.1016 / j.tim.2014.10.007 .