Post-transcriptional modification

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Among post-transcriptional modification , or post-transcriptional modification all modifications of the are mRNA summarized that after the transcription take place partly during ( kotranskriptionell ). Examples are capping , polyadenylation and splicing .

These modifications can increase the stability of the RNA, prepare the mRNA for transport from the nucleus through the nuclear pores into the cytoplasm, and prevent degradation by exonucleases . However, the information content can also be changed after the transcription, for example by cutting out areas of the RNA as so-called introns that do not code, or different variants of related proteins are made possible by alternative splicing of the remaining exons .

Post- transcriptional modifications in this form are only detectable in eukaryotes , since the transcription is spatially separated from the translation here. In the case of prokaryotes, however, there is simultaneous translation of the mRNA that is still produced during transcription. Furthermore, no introns occur.

literature

  • Jeremy M. Berg, John L. Tymoczko, Lubert Stryer : Biochemistry. 6th edition, Spektrum Akademischer Verlag, Heidelberg 2007. ISBN 978-3-8274-1800-5 .
  • Donald Voet, Judith G. Voet: Biochemistry. 3rd edition, John Wiley & Sons, New York 2004. ISBN 0-471-19350-X .
  • Bruce Alberts , Alexander Johnson, Peter Walter, Julian Lewis, Martin Raff, Keith Roberts: Molecular Biology of the Cell , 5th Edition, Taylor & Francis 2007, ISBN 978-0-8153-4106-2 .

Individual evidence

  1. ^ DL Bentley: Coupling mRNA processing with transcription in time and space. In: Nature Reviews Genetics . Volume 15, number 3, March 2014, ISSN  1471-0064 , pp. 163-175, doi : 10.1038 / nrg3662 . PMID 24514444 .
  2. ^ Y. Brody, N. Neufeld, N. Bieberstein, SZ Causse, EM Böhnlein, KM Neugebauer, X. Darzacq, Y. Shav-Tal: The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing. In: PLoS biology. Volume 9, number 1, 2011, ISSN  1545-7885 , p. E1000573, doi : 10.1371 / journal.pbio.1000573 . PMID 21264352 . PMC 3019111 (free full text).