Poison potential theory
The poison potential theory is an outdated theory about the mode of action of drugs and poisons . The pharmacologist Walther Straub suspected that for the effects of some poisons and pharmaceuticals, it is not the absolute amount of poison that is decisive , but rather the gradient between the amount of substance located intracellularly and extracellularly . Some drugs work by crossing the cell membrane . This is only the case with a concentration difference, a concentration potential, between the extra and intracellular space. If the concentrations equalized, the effect ceased.
Individual evidence
- ↑ Klaus Starke: The History of the Pharmacological Institute of the University of Freiburg (PDF; 1.6 MB)
- ↑ Andreas-Holger Maehle: Historical Foundations of the Receptor Concept in Pharmacology ( Memento of the original from November 3, 2013 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. (PDF; 126 kB)
