Receptor theory

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Receptor theory is a term from pharmacology . She explains the effects of various drugs as the interaction of pharmacomolecules or natural ligands with receptors .

history

The receptor theory was introduced by John Newport Langley and Paul Ehrlich .

properties

An essential part of the concept of the receptor theory is that the drug forms a fixed complex with the receptor for a certain period of time .

To understand this, two types of complexes can be distinguished:

  1. The drug forms a complex in which the receptor passes on the complete information to the cell,
  2. The drug forms a complex without triggering an effect itself, but the receptor remains occupied.

Since the transitions between 1 + 2 are fluid, one speaks of intrinsic activity , the intensity of action. An agonist activates a receptor and an antagonist does not activate it or inhibits the binding of the natural ligand.

A detailed receptor theory is PK / PD modeling .

Individual evidence

  1. ↑ BA Ploeger, PH van der Graaf, M. Danhof: Incorporating receptor theory in mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling. In: Drug Metabolism and Pharmacokinetics . Volume 24, Number 1, 2009, pp. 3-15, PMID 19252332 .
  2. ↑ Nature Reviews Drug Discovery 1 , 637-641 (August 2002) doi: 10.1038 / nrd875
  3. ↑ AH Maehle: The quantification and differentiation of the drug receptor theory, c. 1910-1960. In: Annals of science. Volume 62, Number 4, October 2005, pp. 479-500, doi : 10.1080 / 00033790412331312666 . PMID 16482711 .