Roderick Lim

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Roderick Lim (2014)

Roderick Lim (born October 16, 1974 in Singapore ) is a Singapore-born nano- and biophysicist as well as nanobiologist and professor at the Swiss Nanoscience Institute and the Biozentrum of the University of Basel , Switzerland .

Life

Roderick Lim studied physics at the University of North Carolina in Chapel Hill , USA. In 2003 he received his PhD from the National University of Singapore (NUS) on his research work at the Institute of Materials Research and Engineering (IMRE), Singapore. He then went to 2008 as a postdoctoral fellow at the ME Müller Institute for Structural Biology at the Biozentrum of the University of Basel. In 2009 Lim was appointed Argovia Professor for Nanobiology at the Biozentrum and at the Swiss Nanoscience Institute, University of Basel. Roderick Lim has been an Associate Professor at the Biozentrum since 2014.

Act

Roderick Lim is interested in the regulation of the transport processes between the cell nucleus and cytoplasm as well as in their importance for cell function and how findings can be translated into bio-inspired applications. To this end, Lim is investigating how karyopherins simplify rapid and selective transport through nuclear pore complexes (NPCs). In order to clarify the physical principles underlying the biological process, Lim combines biophysical, nanotechnological and cellular processes. The aim is to simulate the results in biomimetic systems. His most important achievements include the karyopherin-centered model of the NPC and his discovery of how two-dimensional transport is controlled in the artificial system. Lim also conducts research in the field of mechanobiology, examining cell mobility and cancer growth. Roderick Lim is one of the inventors of the nanotechnology ARTIDIS® (Automated and Reliable Tissue Diagnostics), an innovation for cancer diagnostics developed on the basis of atomic force microscopy.

Awards

  • 2008 Pierre-Gilles de Gennes Prize: “From Solid State to Biophysics”
  • 2004 International grant from the Agency of Science, Technology and Research (A * STAR, Singapore)

Publications (selection)

Complete list of publications

  • KD Schleicher, SL Dettmer, LE Kapinos, S. Pagliara, UF Keyser, S. Jeney and RYH Lim *. Selective Transport Control on Molecular Velcro made from Intrinsically Disordered Proteins. Nature Nanotechnology, advance online publication. doi : 10.1038 / NNANO.2014.103 PMID 24929341
  • LE Kapinos, RL Schoch, RS Wagner, KD Schleicher and RYH Lim *. Karyopherin-centric Control of Nuclear Pores based on Molecular Occupancy and Kinetic Analysis of Multivalent Binding with FG-Nucleoporins. Biophys. J. 106 1751 (2014) PMID 24739174
  • M. Plodinec, M. Loparic, CA Monnier, EC Obermann, R. Zanetti-Dallenbach, P. Oertle, JT Hyotyla, U. Aebi, M. Bentires-Alj, RYH Lim * and CA. Schoenenberger, The Nanomechanical Signature of Breast Cancer, Nature Nanotechnology 7 757 (2012) PMID 23085644
  • RL Schoch, LE Kapinos, and RYH Lim *, Nuclear Transport Receptor Binding Avidity Triggers a Self-Healing Collapse Transition in FG-Nucleoporin Molecular Brushes, PNAS 109 16911 (2012) PMID 23043112
  • SW Kowalczyk, LE Kapinos, T. Magalhães, P. van Nies, RYH Lim *, and C. Dekker *, Single-Molecule Transport Across an Individual Biomimetic Nuclear Pore Complex, Nature Nanotechnology 6, 433 (2011) PMID 21685911
  • RYH Lim *, B. Fahrenkrog, J. Koser, K. Schwarz-Herion, J. Deng, and U. Aebi, Nanomechanical Basis of Selective Gating by the Nuclear Pore Complex, Science 318 640 (2007) PMID 17916694
  • RYH Lim *, NP Huang, J. Koser, J. Deng, KHA Lau, K. Schwarz-Herion, B. Fahrenkrog, and U. Aebi, Flexible Phenylalanine-Glycine Nucleoporins as Entropic Barriers to Nucleocytoplasmic Transport. PNAS 103 9512 (2006) PMID 16769882
  • R. Lim and SJ O'Shea, Solvation Forces in Branched Molecular Liquids, Physical Review Letters 88 246101 (2002) PMID 12059317

Web link

Video link

Individual evidence

  1. ↑ Ph.D Theses National University of Singapore (NUS) . nus.edu.sg, accessed September 9, 2014
  2. ↑ Curriculum Vitae. Biozentrum.unibas.ch, accessed on April 16, 2019 .
  3. ↑ "Feeling" the dangers of cancer. unibas.ch, archived from the original on September 10, 2014 ; Retrieved September 9, 2014 .
  4. ↑ Complete list of publications Biozentrum.unibas.ch, accessed on September 9, 2014.

Remarks

  1. ↑ The English Wikipedia has an article about the Swiss Nanoscience Institute .
personal data
SURNAME Lim, Roderick
ALTERNATIVE NAMES Lim Yu Hin, Roderick
BRIEF DESCRIPTION Singaporean nano- and biophysicist and nanobiologist
DATE OF BIRTH October 16, 1974
PLACE OF BIRTH Singapore