Serotonylation

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The serotonylation is a biochemical process in which the biogenic amine serotonin on glutamine residues of proteins using the enzyme transglutaminase is transmitted II. Target proteins for this process are in particular small GTPases . Serotonylation takes place as an intracellular process inside the cell and is used to control signal transmission within the cell . The function of serotonin in serotonylation thus differs from its function as a tissue hormone and neurotransmitter, which is used for cell-to-cell communication . Serotonylation is assumed to play an important role in blood clotting and in regulating the release of insulin .

Individual evidence

  1. ↑ Walther DJ, Peter JU, Winter S, et al. : Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release . In: Cell . 115, No. 7, December 2003, pp. 851-862. doi : 10.1016 / S0092-8674 (03) 01014-6 . PMID 14697203 .
  2. ↑ Paulmann N, Grohmann M, Voigt JP, et al. : Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation . In: PLoS Biol . . 7, No. 10, October 2009, p. E1000229. doi : 10.1371 / journal.pbio.1000229 . PMID 19859528 . PMC 2760755 (free full text).