Specific target organ toxicity

The specific target organ toxicity ( Engl. Specific Target Organ Toxicity, STOT ) refers to a hazard class of chemicals for which the Regulation (EC) no. 1272/2008 (of 16 December 2008 Regulation CLP ) prescribes a certain labeling and packaging.

A distinction is made between the specific target organ toxicity after single exposure (STOT SE) and after repeated exposure (STOT RE). The classification criteria result from 3.8 and 3.9 of Annex I of the CLP regulation (regulations for the classification and labeling of dangerous substances and mixtures).

The specific target organ toxicity after single exposure describes the specific non-lethal target organ toxicity after a single exposure, the target organ toxicity after repeated exposure the specific target organ toxicity after repeated exposure to a substance or a mixture. This includes all clear health effects that can affect bodily functions, regardless of whether they are reversible or irreversible, immediate and / or delayed. In addition to animal studies , empirical values in humans, such as the development of occupational diseases, are used as a basis for assessment .

STOT SE has categories SE1, SE2 and SE3, STOT RE only RE1 and RE2.

Specific target organ toxicity can occur through all relevant routes of exposure , with oral, dermal and inhalation being the most important. The following organ systems in particular can be affected:

• Enterotoxicity
• Gonadotoxicity
• Haematotoxicity
• Hepatotoxicity
• Cardiotoxicity
• Myelotoxicity
• Nephrotoxicity
• Neurotoxicity
• Ototoxicity
• Pneumotoxicity

Individual evidence

1. ↑ cf. Risk assessment of dermal exposure for substances of the hazard class "Specific Target Organ Toxicity" (STOT) according to the CLP regulation website of the DGUV , as of March 2013
2. ↑ Specific target organ toxicity (single exposure)
3. ↑ Specific target organ toxicity (repeated exposure)
4. ↑ Annex I Regulation (EC) No. 1272/2008 of the European Parliament and of the Council of December 16, 2008 on the classification, labeling and packaging of substances and mixtures, amending and repealing Directives 67/548 / EEC and 1999/45 / EG and amending Regulation (EG) No. 1907/2006 jurion.de, accessed on February 17, 2019
5. ↑ GHS - the hazard classes German / English professional association for food and hospitality , accessed on February 17, 2019
6. ↑ 3.8.1 and 3.9.1 Annex I of the CLP Regulation