Sternberg giant cell

from Wikipedia, the free encyclopedia
Sternberg giant cell

Sternberg or Sternberg-Reed giant cells (after the Austrian pathologist Carl Sternberg and the American pediatrician Dorothy Reed Mendenhall ) are pathologically altered B-lymphocytes that occur primarily in Hodgkin's lymphoma . They arise through mitosis without separation of the cell body from Hodgkin cells . Sternberg giant cells, however, are not indicative of Hodgkin's lymphoma; they can also occur in non-Hodgkin's lymphoma , Pfeiffer glandular fever and also in sarcomas and carcinomas .

Sternberg-Reed giant cells are monoclonal B lymphocytes that arise in the germinal center of lymph nodes . In the classic form they have two or more cell nuclei and large, eosinophilic nuclear bodies . In the cells, there is a new combination of immunoglobulin - genes . In the classical form of expressing an interleukin 2 - receptor ( CD25 ), as well as the B-lymphocyte antigens CD19 and CD20 .

Individual evidence

  1. ^ Roche Lexicon Medicine . Elsevier Health Sciences, 2003, ISBN 978-3-437-15156-9 , pp. 1754 .
  2. ↑ Donald W. Kufe et al .: Holland Frei Cancer Medicine . tape 8 . Pmph USA, 2010, ISBN 978-1-60795-014-1 , pp. 1624 .
  3. ↑ Wolfgang Piper: Internal medicine . 2nd Edition. Springer, Berlin 2012, ISBN 978-3-642-33108-4 , pp. 683 .