Stress leukogram

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The typical changes in the differential blood count during stress and acute illnesses are called stress leukograms . It is triggered by high cortisol levels and is therefore also typical of Cushing's syndrome , but not specific. A stress leukogram is characterized by an increase in neutrophil granulocytes in the blood ( neutrophilia ), a decrease in lymphocytes ( lymphopenia ) and eosinophils ( eosinopenia ), and often an increase in monocytes ( monocytosis ).

Neutrophilia is triggered by an increased release of mature granulocytes from the bone marrow , possibly also by the migration of granulocytes from the periphery into the bloodstream and by a reduced migration from the bloodstream to the periphery. Lymphopenia is caused by a redistribution of the lymphocytes in the circulating blood, possibly also by a lysis of the lymphocytes. Eosinopenia is caused by steroid-dependent storage of eosinophils in the bone marrow and other tissues. In monocytosis, too, a redistribution of monocytes from the periphery into the circulating blood is assumed to be the cause.


  • AE Schultze: Interpretation of canine leukocyte responses. In: DJ Weiss, KJ Wardrop (eds.): Schalm's Veterinary Hematology. 6th edition, Wiley-Blackwell , 2010, ISBN 978-0-8138-1798-9 , pp. 321-334.