Subiculum
The subiculum is part of the limbic system , more precisely the hippocampus .
It connects the hippocampus with the parahippocampal gyrus , and it is believed today that it is the ultimate authority for information processing in the hippocampus.
It is located in the vicinity of the Ammon's horn ( Cornu Ammonis ), which is located in the archicortex (an older part of the cerebral cortex ) in the temporal lobe . Within the Ammon's horn, a distinction is made between different areas or surface structures (depending on the type of cells occurring there). These include the
- Dentate gyrus
- Hippocampal sulcus
- Sulcus fimbriodentatus
- Fimbria hippocampi
- Alveus hippocampi
The transition area between Ammon's horn and the adjacent entorhinal cortex is called the subiculum . The cortical band of the hippocampus is divided into four sections according to its width, cell size and cell density: CA1 (CA for Cornu Ammonis) to CA4. The subiculum gets afferents from the CA1 cells. Efferents go from the subiculum to the nucleus ambiguus , the amygdala , the prefrontal cortex and the hypothalamus . Both afferents and efferents exist with the perirhinal cortex and the entorhinal cortex.
Clinical significance
Possible role in Alzheimer's disease
Rat studies indicate that a lesion of the subiculum reduces the spread of amyloid beta in rat models of Alzheimer's disease . Alzheimer's disease pathology is believed to have prion- like properties. The disease tends to spread from the entorhinal cortex through the subiculum in a characteristic order.
Individual evidence
- ↑ Sonia George, Annica Rönnbäck, Gunnar K Gouras, Géraldine H Petit, Fiona Grueninger: Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease . In: Acta Neuropathologica Communications . tape 2 , February 11, 2014, ISSN 2051-5960 , p. 17 , doi : 10.1186 / 2051-5960-2-17 , PMID 24517102 , PMC 3932948 (free full text).