Target Controlled Infusion

Target Controlled Infusion (TCI) refers to the targeted infusion of drugs using microchip- controlled syringe pumps . Thus, the TCI ensures a constant, user-defined plasma level.

pharmacology

The goal of TCI is relatively simple, to maintain the plasma concentration of a particular drug in the body. The doctor defines the desired "goal" himself.

The goals can be as follows:

• adequate analgesia of an opioid
• desired plasma concentration of a hypnotic drug

The TCI is used especially for anesthesia techniques, where from a certain plasma level sufficient analgesia and anesthesia can be expected and below a certain plasma level the patient can be expected to wake up. Such anesthesia is total intravenous anesthesia ( TIVA ) with propofol and various opioids .

Context-sensitive half-life

In addition, when choosing the drug, particular attention must be paid to the context-sensitive half-life of the drug.

drug

Opioids

Even if the number of hypnotics and opioids and Germany is very high, opioids such as fentanyl and fentanyl preparations ( remifentanil , sufentanil , etc.) are used "routinely" for this .

Hypnotic

The "standard hypnotic" of an anesthetist is propofol . In order to be able to guarantee safe anesthesia, a TCI is often an option.

Benzodiazepines

As a rule, benzodiazepines are administered as a bolus . Especially when you look at the published table (context-sensitive half-life), you quickly notice that the use of Benzos makes less sense here.

literature

• S. Schraag, J. Flaschar, M. Georgieff: Target Controlled Infusion (TCI) - Importance and Clinical Perspectives. In: Anasthesiol Intensivmed Emergency Med Schmerzther. 35 (1), Jan 2000, pp. 12-20. PMID 10689517

Individual evidence

1. ^ ^{A b c} Wilhelm, Wolfram .: Practice of anesthesiology. Berlin, ISBN 978-3-662-54568-3 .

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !