Terence Rabbitts

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Terence Rabbitts

Terence Howard Rabbitt's FRS FMedSci (born June 17, 1946) is Professor of Molecular Biology at the University of Oxford .

Scientific CV

Rabbitts graduated from John Ruskin College, graduated from the University of East Anglia, and earned a PhD from the National Institute for Medical Research . In 1981 he was awarded the Colworth Medal, in 1987 he became a Fellow of the Royal Society and in 1998 a Fellow of the Academy of Medical Sciences.

Research activities

Rabbitts is one of the pioneers in method development in the field of cDNA cloning . 1975 published his first research on immunoglobulin genes together with César Milstein at the Laboratory of Molecular Biology . In the following years he dealt with the mechanisms of the development of antibody diversity. In the course of his work on the chromosomal localization of the light chains of the antibody genes, his group began investigating the genetics of the myc oncogene in Burkitt's lymphoma. In the mid-1980s, his group began developing chimeric antibodies. At the same time, Rabbitts took part in the investigations into the rapidly developing area of ​​the newly discovered TCR genes (especially the TCR delta locus), with a particular interest in the connection between chromosomal translocations in the T cell receptor genes in the development of T Cell leukemias. His working group studied two families of oncogenes, the so-called LIM oncogenes and the family of HOX genes. In the early 1990s, his group discovered a fusion gene as the likely cause of malignant liposarcoma. He was thus one of the pioneers in the investigation of fusion genes in solid tumors and once again confirmed the importance of chromosomal translocations in tumor development. In early 2000 he studied the possibilities of using intracellular antibodies in the treatment of CML. and began work on developing the knock-in technique that he had prepared with the studies on the synthetic generation of targeted chromosomal translocations. In the last few years he began to combine these methods (intracellular antibodies and knock-in genes) in order to examine the therapeutic potential of the targeted intracellular influencing of protein-protein interactions in oncogenes.

Web links

Individual evidence

  1. ↑ Rabbitts, Prof. Terence Howard. In: Who's Who 2014. Online edition, A&C Black, an imprint of Bloomsbury Publishing plc, 2014, Oxford University Press, 2013.
  2. ^ Transactions of the Biochemical Society
  3. ^ Professor Terence Rabbitt's FRS FMedSci
  4. ^ TH Rabbitts: Bacterial cloning of plasmids carrying copies of rabbit globin messenger RNA. In: Nature . 260, No. 5548, 1976, pp. 221-225, PMID 768776 .
  5. ^ TH Rabbitts, C. Milstein: Mouse immunoglobulin genes: studies on the reiteration frequency of light-chain genes by hybridization procedures. In: European Journal of Biochemistry . 52, No. 1, 1975, pp. 125-133, PMID 51793 .
  6. ↑ TH Rabbitts, JM Jarvis, C. Milstein: Demonstration that a mouse immunoglobulin light chain messenger RNA hybridizes exclusively with unique DNA. In: Cell . 6, No. 1, 1975, pp. 5-12, PMID 809142 .
  7. ^ DL Bentley, TH Rabbitts: Human V kappa immunoglobulin gene number: implications for the origin of antibody diversity. In: Cell. 24, No. 3, 1981, pp. 613-623, PMID 6265099 .
  8. ↑ S. Malcolm, P. Barton, C. Murphy, MA Ferguson-Smith, DL Bentley, TH Rabbitts: Localization of human immunoglobulin kappa light chain variable region genes to the short arm of chromosome 2 by in situ hybridization. In: Proceedings of the National Academy of Sciences . 79, No. 16, 1982, pp. 4957-4961, PMID 6812058 .
  9. ↑ PH Hamlyn, TH Rabbitts: Translocation joins c-myc and immunoglobulin gamma 1 genes in a Burkitt lymphoma revealing a third exon in the c-myc oncogene. In: Nature. 304, No. 5922, 1983, pp. 135-139, PMID 6306472
  10. ↑ MS Neuberger, GT Williams, EB Mitchell, SS Jouhal, JG Flanagan, TH Rabbitts: A hapten-specific chimaeric IgE antibody with human physiological effector function. In: Nature. 314, No. 6008, 1985, pp. 268-270, PMID 2580239 .
  11. ↑ T. Boehm, R. Baer, ​​I. Lavenir, A. Forster, JJ Waters, E. Nacheva, TH Rabbitts: The mechanism of chromosomal translocation t (11; 14) involving the T-cell receptor C delta locus on human chromosome 14q11 and a transcribed region of chromosome 11p15. In: The EMBO Journal . 7, No. 2, 1988, pp. 385-394, PMID 3259177 .
  12. ^ TH Rabbitts, MP Lefranc, MA Stinson, JE Sims, J. Schroder, M. Steinmetz, NL Spurr, E. Solomon, PN Goodfellow: The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia. In: The EMBO Journal. 4, No. 6, 1985, pp. 1461-1465, PMID 3875483 .
  13. ↑ T. Boehm, L. Foroni, Y. Kaneko, MF Perutz, TH Rabbitts: The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. In: Proceedings of the National Academy of Sciences . 88, No. 10, 1991, pp. 4367-4371, PMID 2034676 .
  14. ↑ MA Kennedy, R. Gonzalez-Sarmiento, UR Kees, F. Lampert, N. Dear, T. Boehm, TH Rabbitts: HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24. In: Proceedings of the National Academy of Sciences . 88, No. 20, 1991, pp. 8900-8904, PMID 1681546 .
  15. ^ TH Rabbitts, A. Forster, R. Larson, P. Nathan: Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t (12; 16) in malignant liposarcoma. In: Nature Genetics . 4, No. 2, 1993, pp. 175-180, doi : 10.1038 / ng0693-175 , PMID 7503811 .
  16. ^ TH Rabbitts: Chromosomal translocations in human cancer. In: Nature. 372, No. 6502, 1994, pp. 143-149, doi : 10.1038 / 372143a0 , PMID 7969446 .
  17. ↑ Eric Tse, M. Natividad Lobato, Alan Forster, Tomoyuki Tanaka, Grace TY Chung, Terence H. Rabbitts: Intracellular antibody capture technology: application to selection of intracellular antibodies recognizing the BCR-ABL oncogenic protein. In: Journal of Molecular Biology . 317, No. 1, 2002, pp. 85-94, doi : 10.1006 / jmbi.2002.5403 , PMID 11916380 .
  18. ↑ Alan Forster, Richard Pannell, Lesley F. Drynan, Rosalind Codrington, Angelika Daser, Markus Metzler, M. Natividad Lobato, Terence H. Rabbitts: The invertor knock-in conditional chromosomal translocation mimic. In: Nature Methods . 2, No. 1, 2005, pp. 27-30, doi : 10.1038 / nmeth727 , PMID 15782166 .
  19. ^ Alan Forster, Richard Pannell, Lesley F. Drynan, Matthew McCormack, Emma C. Collins, Angelika Daser, Terence H. Rabbitts: Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer. In: Cancer Cell . 3, No. 5, 2003, pp. 449-458, PMID 12781363 .
  20. ↑ Tomoyuki Tanaka, Terence H. Rabbitts: Protocol for the selection of single-domain antibody fragments by third generation intracellular antibody capture. In: Nature Protocols. 5, No. 1, 2010, pp. 67-92, doi : 10.1038 / nprot.2009.199 , PMID 20057382 .
  21. ↑ Jing Zhang, Terence H. Rabbitts: Intracellular antibody capture: A molecular biology approach to inhibitors of protein-protein interactions. In: Biochimica et Biophysica Acta . 1844, No. 11, 2014, pp. 1970–1976, doi : 10.1016 / j.bbapap.2014.05.009 , PMID 24881582 .
personal data
SURNAME Rabbitts, Terence
ALTERNATIVE NAMES Rabbitts, Terence Howard
BRIEF DESCRIPTION English molecular biologist and university professor
DATE OF BIRTH June 17, 1946