The European Mouse Mutant Archive
| The European Mouse Mutant Archive (EMMA) |
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| purpose | Archiving mutant mouse lines |
| Chair: | Martin Hrabĕ de Angelis (Director) |
| Establishment date: | 1999 |
| Seat : |
Consiglio Nazionale delle Ricerche (Monterotondo Italy )
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| Website: | The European Mouse Mutant Archive |
The European Mouse Mutant Archive (EMMA) is a consortium founded in 1999 for the collection and archiving of research-relevant mouse mutants by means of cryopreservation . At the project seven European total research institutes involved, the headquarters of the Consiglio Nazionale delle Ricerche (CNR) near Rome .
purpose
The genome of the house mouse ( Mus musculus ) is very similar to that of humans. That is why it is used in research as a model organism for human diseases. In addition, numerous molecular biological methods for the production of mutant mouse lines have emerged in the last 30 years. Do you want z. For example, to find out what a certain mouse gene is responsible for, it is possible to switch off this gene in a targeted manner ( gene knockout ) to see what effects this has on the organism. In order to be able to continue working with such a mouse, one possibility is to breed a mouse line whose offspring all carry this defect. However, this is complex and expensive. Another option is cryopreservation, in which embryos with the defect can be frozen in liquid nitrogen and stored for any length of time.
The organization uses the second method and has set itself the task of preserving a wide variety of mouse mutants and making them available to research institutes if necessary.
Members
The consortium consists of six regular members as well as the EMBL , which is responsible for the online databases.
- CNR Istituto di Biologia Cellulare in Monterotondo, Italy
- CNRS Center de Distribution de Typage et d'Archivage animale in Orleans, France
- MRC Mammalian Genetics Unit in Harwell, UK
- Karolinska Institutet in Stockholm, Sweden
- Instituto Gulbenkian de Ciência in Oeiras, Portugal
- Helmholtz Zentrum München Institute of Experimental Genetics in Munich, Germany
- EMBL European Molecular Biology Laboratory
- EBI European Bioinformatics Institute in Hinxton, UK (part of EMBL)
Web links
- Brochure from the Helmholtz Center Munich (formerly GSF) about the European Mouse Mutant Archive (PDF)
Individual evidence
- ↑ Information from the Federal Ministry of Education and Research, Combating Disease Through Genome Research - The National Genome Research Network ( Memento of July 20, 2004 in the Internet Archive ) (accessed on March 9, 2010)
- ↑ NGFN website, European Mouse Mutant Archive (accessed March 9, 2010)