Martin Hrabě de Angelis

from Wikipedia, the free encyclopedia
Martin Hrabě de Angelis
Martin Hrabě de Angelis

Martin Hrabě de Angelis (born October 29, 1964 in Gießen ) is a German geneticist and executive director of the Institute for Experimental Genetics at the Helmholtz Center in Munich and director of the European Mouse Mutant Archive (EMMA) in Monterotondo . Since 2003 he has held the chair for experimental genetics at the Technical University of Munich . He is co-founder, speaker and board member of the German Center for Diabetes Research e. V. (DZD). His main research interests are metabolism and diabetes , large scale functional genomics / genetics and epigenetics .

Career

Hrabě de Angelis studied biology at the Philipps University in Marburg and received his doctorate in 1994 on the influence of growth factors on early embryonic development (1985–1994). From 1994 to 1997 he was a postdoctoral fellow at the Jackson Laboratory in Bar Harbor (USA). There he analyzed the deltagens of the mouse and examined mouse mutations as a model for the thusogenesis. From 1997 to 2000, Hrabě de Angelis was head of the “Functional Genetics” working group at the Institute for Mammalian Genetics of the then Society for Radiation Research, GSF, (today Helmholtz Zentrum München ).

Since 2000 he has been director of the Institute for Experimental Genetics at the Helmholtz Zentrum München, and in 2003 he was appointed to the Chair of Experimental Genetics at the Technical University of Munich. He is also director of the pan-European research consortium INFRAFRONTIER. In 2001, Hrabě de Angelis founded the German Mouse Clinic (GMC) for the systemic analysis of human diseases. The focus of research is the elucidation of genetic and epigenetic factors of diabetes mellitus. In 2009, Hrabě de Angelis co-founded the German Center for Diabetes Research e. V. (DZD) and is spokesman and board member. In 2017 he took over the presidency of the International Mammal Genome Society.

Using the mouse model, Hrabě de Angelis demonstrated that obesity and diabetes caused by diet can be passed on epigenetically to the offspring via both egg cells and sperm. By studying knockout mice, each of which was missing a precisely selected gene , he was able to identify a network of genes that could play an important role in the development of metabolic diseases such as diabetes.

Hrabě de Angelis published more than 500 scientific articles (Google Scholar Quotes: 26,271) as well as numerous contributions in specialist books.

Awards and honors (selection)

Memberships in scientific societies (selection)

  • Since 1999 member of the “Mutagenesis Scientific Advisory Board” (SAB), Jackson Laboratory
  • 2006–2009 speaker of the project committee of the "National Genome Research Network"
  • Since 2008 coordinator "INFRAFRONTIER - Functional Genomics in the Mouse as a Model"
  • Since 2009 board member of the German Center for Diabetes Research eV (DZD)             
  • Since 2009 board member of the "International Mouse Phenotyping Consortium (IMPC)"

Web links

Individual evidence

  1. ↑ Genetic Research Current. (PDF; 1.9 MB) National Genome Research Network (NGFN), September 14, 2006, p. 45 , accessed on October 12, 2019 .
  2. ↑ Professor profile: Hrabe de Angelis Martin. Retrieved April 16, 2019 .
  3. ↑ Helmholtz Zentrum München: You are what your parents ate! - Helmholtz Centre Munich. Retrieved April 16, 2019 .
  4. ↑ 404 - page not found. Retrieved April 16, 2019 .
  5. ↑ Martin Hrabe de Angelis - Google Scholar Citations. Retrieved April 16, 2019 .
  6. ↑ Paula and Richard von Hertwig Prize for interdisciplinary collaboration for new findings in diabetes research - Helmholtz Center Munich. Retrieved April 16, 2019 .
  7. ↑ Honorary doctorate for DZD board. Retrieved April 16, 2019 .
  8. ↑ Double honorary doctorate for Martin Hrabě de Angelis - Helmholtz Center Munich. Retrieved April 16, 2019 .
  9. ↑ Keeping the big picture in view - Honorary doctorate for Professor Dr. Martin Hrabě de Angelis. Retrieved April 16, 2019 .
personal data
SURNAME Hrabě de Angelis, Martin
BRIEF DESCRIPTION German geneticist
DATE OF BIRTH October 29, 1964
PLACE OF BIRTH to water