German Center for Diabetes Research

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German Center for Diabetes Research

Founding: June 24, 2009 in Berlin
Organization: Registered association (eV)
Sponsorship: state
Place: Neuherberg near Munich (office)
Annual budget: 33.3 million euros per year (90 percent federal, 10 percent federal states, which are the headquarters of the DZD locations)
Manager: Astrid Glaser
Board: Martin Hrabě de Angelis (Helmholtz Center Munich), Michael Roden (German Diabetes Center), Michele Solimena (University of Dresden)
Website: www.dzd-ev.de

The German Center for Diabetes Research eV (DZD), based in Neuherberg near Munich, was commissioned by the Federal Ministry of Education and Research (BMBF) from the interdisciplinary cooperation of the German Diabetes Center, German Institute for Nutrition and the Helmholtz Center Munich - German Research Center for Health and Environment - founded with the University of Tübingen and the University Hospital Dresden as a center for research into the widespread disease diabetes mellitus .

history

In 2008, the Federal Ministry of Education and Research decided to establish health research centers for common diseases. After the German Center for Neurodegenerative Diseases , the German Center for Diabetes Research was founded on June 24, 2009. At the end of 2019, the following institutes were partners in the DZD:

To establish the institute, an association was founded in 2009 in which the following institutes for diabetes research from Germany are represented. The network includes:

Associated partners are research groups in the field of metabolism and diabetes at the universities in Heidelberg, Cologne, Leipzig, Munich and Schleswig-Holstein.

The institute was funded by the BMBF with 8 million euros in 2010 for research work, and the funds are to increase further over the next four years. From 2014 the institute will be funded with 33 million euros annually.

Focus

  • Prevention of various forms of diabetes mellitus
  • Causes and treatment of non-alcoholic fatty liver disease
  • Insulin action and insulin resistance in the brain
  • Protection and regeneration of islet cells in type 1 diabetes
  • Influence of genetics and epigenetics on the development of different forms of diabetes mellitus
  • Consequences of diabetes mellitus
  • Type 1 diabetes: origin, mechanisms, prevention

Important results over the past 10 years

  • With the Diabetes Risk Test®, adults can determine their risk of developing type 2 diabetes within the next five years.
  • Type 1 diabetes is an autoimmune disease. Insulin swallowed as a powder could prevent the outbreak. Randomized, placebo-controlled studies are currently ongoing.
  • Type 2 diabetes does not arise overnight. Researchers found proteins and other metabolic products in the blood of high-risk patients that can be used as markers to predict risks.
  • Effects of lifestyle, such as obesity, can be inherited via mechanisms of epigenetics. The risk is increased in the offspring of patients.
  • DZD scientists have identified more than 50 new genes that are associated with metabolic diseases.
  • Gestational diabetes not only changes the mother's metabolism, but also affects fetal development. It is believed that this increases the risk of obesity and type 2 diabetes.
  • Researchers at the DZD were able to show in the laboratory that a Teflon membrane protects insulin-producing beta cells from the attack of the immune system in type 1 diabetes. Hormones and nutrients can cross the membrane. The work is based on an artificial pancreas, which is currently being researched.
  • Discovery of key molecular functions of stem cell differentiation that could be used for beta cell replacement therapy in diabetes.
  • A triple hormone simulates the effect of glucagon-like peptide 1 (GLP-1), the glucose-dependent insulinotropic peptide (GIP) and glucagon. In animal experiments it reduced blood sugar levels, appetite and body fat. Clinical studies are now under way.
  • Our brain is an insulin-sensitive organ. Altered neuronal processes are involved in the development of insulin resistance.
  • One in three adults in western countries has fatty liver disease. Studies have shown that especially the fetuin A level, the fatty liver status and the fatty acid levels indicate an increased risk of type 2 diabetes.
  • Type 2 diabetes is not a single disease. Rather, there are various subgroups that have a different risk of complications.

Diabetes information portal Diabinfo.de

In order to provide people with diabetes and interested parties with information about diabetes and its prevention, the DZD set up the national diabinfo.de information portal on the initiative of the Federal Center for Health Education (BZgA).

Web links

Individual evidence

  1. ↑ BMBF press release Accessed : February 9, 2018.
  2. ↑ locations. Retrieved March 16, 2020 .
  3. ↑ Health Research Program 2011  ( page no longer available , search in web archives )  Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice. Retrieved January 23, 2011.@1@ 2Template: Toter Link / www.bmbf.de  
  4. ↑ Rebecca Paprott, Kristin Mühlenbruch, Gert BM Mensink, Silke Thiele, Matthias B. Schulze: Validation of the German Diabetes Risk Score among the general adult population: findings from the German Health Interview and Examination Surveys . In: BMJ Open Diabetes Research and Care . tape 4 , no. 1 , November 1, 2016, ISSN  2052-4897 , p. e000280 , doi : 10.1136 / bmjdrc-2016-000280 .
  5. ↑ Anette-G. Ziegler, Ezio Bonifacio, Alvin C. Powers, John A. Todd, Leonard C. Harrison: Type 1 Diabetes Prevention: A Goal Dependent on Accepting a Diagnosis of an Asymptomatic Disease . In: Diabetes . tape 65 , no. 11 , November 1, 2016, ISSN  0012-1797 , p. 3233-3239 , doi : 10.2337 / db16-0687 , PMID 27959859 .
  6. ↑ Christine von Toerne, Cornelia Huth, Tonia de las Heras Gala, Florian Kronenberg, Christian Herder: MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study . In: Diabetologia . tape 59 , no. 9 , September 1, 2016, ISSN  1432-0428 , p. 1882-1892 , doi : 10.1007 / s00125-016-4024-2 .
  7. ↑ Clemens Wittenbecher, Meriem Ouni, Olga Kuxhaus, Markus Jähnert, Pascal Gottmann: Insulin-Like Growth Factor Binding Protein 2 (IGFBP-2) and the Risk of Developing Type 2 Diabetes . In: Diabetes . tape 68 , no. 1 , January 1, 2019, ISSN  0012-1797 , p. 188-197 , doi : 10.2337 / db18-0620 , PMID 30396904 .
  8. ↑ Peter Huypens, Steffen Sass, Moya Wu, Daniela Dyckhoff, Matthias Tschöp: Epigenetic germline inheritance of diet-induced obesity and insulin resistance . In: Nature Genetics . tape 48 , no. 5 , May 2016, ISSN  1546-1718 , p. 497-499 , doi : 10.1038 / ng.3527 .
  9. ↑ Jan Rozman, Birgit Rathkolb, Manuela A. Oestereicher, Christine Schütt, Aakash Chavan Ravindranath: Identification of genetic elements in metabolism by high-throughput mouse phenotyping . In: Nature Communications . tape 9 , no. 1 , January 18, 2018, ISSN  2041-1723 , p. 1-16 , doi : 10.1038 / s41467-017-01995-2 .
  10. ↑ Katarzyna Linder, Franziska Schleger, Isabelle Kiefer-Schmidt, Louise Fritsche, Stefanie Kümmel: Gestational Diabetes Impairs Human Fetal Postprandial Brain Activity . In: The Journal of Clinical Endocrinology & Metabolism . tape 100 , no. 11 , November 1, 2015, ISSN  0021-972X , p. 4029-4036 , doi : 10.1210 / jc.2015-2692 .
  11. ↑ Barbara Ludwig, Stefan Ludwig, Anja Steffen, Yvonne Knauf, Baruch Zimerman: Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes . In: Proceedings of the National Academy of Sciences . tape 114 , no. 44 , October 31, 2017, ISSN  0027-8424 , p. 11745-11750 , doi : 10.1073 / pnas.1708420114 , PMID 29078330 .
  12. ↑ Yoav Evron, Clark K. Colton, Barbara Ludwig, Gordon C. Weir, Baruch Zimermann: Long-term viability and function of transplanted islets macroencapsulated at high density are achieved by enhanced oxygen supply . In: Scientific Reports . tape 8 , no. 1 , April 25, 2018, ISSN  2045-2322 , p. 1-13 , doi : 10.1038 / s41598-018-23862-w .
  13. ↑ Silvia Engert, Ingo Burtscher, W. Perry Liao, Stanimir Dulev, Gunnar Schotta: Wnt / β-catenin signaling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse . In: Development . tape 140 , no. 15 , August 1, 2013, ISSN  0950-1991 , p. 3128-3138 , doi : 10.1242 / dev.088765 , PMID 23824574 .
  14. ↑ Erik Bader, Adriana Migliorini, Moritz Gegg, Noah Moruzzi, Jantje Gerdes: Identification of proliferative and mature β-cells in the islets of Langerhans . In: Nature . tape 535 , no. 7612 , July 2016, ISSN  1476-4687 , p. 430-434 , doi : 10.1038 / nature18624 .
  15. ^ Brian Finan, Bin Yang, Nickki Ottaway, David L. Smiley, Tao Ma: A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents . In: Nature Medicine . tape 21 , no. 1 , January 2015, ISSN  1546-170X , p. 27-36 , doi : 10.1038 / nm.3761 .
  16. ↑ Martin Heni, Stephanie Kullmann, Hubert Preissl, Andreas Fritsche, Hans-Ulrich Häring: Impaired insulin action in the human brain: causes and metabolic consequences . In: Nature Reviews Endocrinology . tape 11 , no. December 12 , 2015, ISSN  1759-5037 , p. 701–711 , doi : 10.1038 / nrendo.2015.173 .
  17. ↑ Gerald I. Shulman: Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease . In: New England Journal of Medicine . tape 371 , no. 12 , September 18, 2014, ISSN  0028-4793 , p. 1131-1141 , doi : 10.1056 / NEJMra1011035 , PMID 25229917 .
  18. ↑ Oana P. Zaharia, Klaus Strassburger, Alexander Strom, Gidon J. Bönhof, Yanislava Karusheva: Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study . In: The Lancet Diabetes & Endocrinology . tape 7 , no. 9 , September 1, 2019, ISSN  2213-8587 , p. 684-694 , doi : 10.1016 / S2213-8587 (19) 30187-1 , PMID 31345776 .
  19. ↑ BZgA: National Diabetes Information Portal www.diabinfo.de. Retrieved March 16, 2020 .

Coordinates: 48 ° 13 ′ 16.2 "  N , 11 ° 35 ′ 38.3"  E