German Diabetes Center

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German Diabetes Center (DDZ)
(Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf)
German Diabetes Center (DDZ) (Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf)
The German Diabetes Center
Category: research Institute
Carrier: German Diabetes Research Society
Legal form of the carrier: Registered association
Seat of the wearer: Dusseldorf
Membership: Leibniz Association
Facility location: Dusseldorf
Type of research: Basic research
Subjects: Natural sciences
Areas of expertise: Clinical Diabetology , Clinical Biochemistry and Pathobiochemistry , Biometry and Epidemiology
Basic funding: Federal government (50%), states (50%)
Management: Michael Roden (Scientific Director) ,
Andreas Fidelak (Commercial Director)
Employee: approx. 240 (as of December 2019)
Annotation: Affiliated institute of Heinrich Heine University Düsseldorf
Homepage: www.ddz.de

The German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University (HHU) , is a non-university research institution based in Düsseldorf . It was founded in 1964 on the initiative of Karl Oberdisse as the "Society for the Promotion of Research into Diabetes eV". The DDZ conducts transdisciplinary research into diabetes mellitus . The aim is the prevention, early detection, diagnosis and therapy of diabetes and its accompanying and secondary diseases. The research focuses on application-oriented basic research in the field of clinical diabetology , clinical biochemistry and pathobiochemistry , biometrics and epidemiology as well as care and health economics . Questions about risk genes, mechanisms, individual lifestyles in combination with environmental influences and their long-term effects on the population and its supply play a decisive role. This is done in extensive clinical studies such as the German Diabetes Study (GDS), which examines the course and consequences over many years. Scientific managing director and spokesman for the board of directors of the DDZ and director of the Institute for Clinical Diabetology has been Michael Roden since 2008 , who also heads the Clinic for Endocrinology and Diabetology at the University Hospital Düsseldorf .

The research center is sponsored by the German Diabetes Research Association and is an affiliated institute of the HHU as a “Leibniz Center for Diabetes Research” and a member of the Gottfried Wilhelm Leibniz Scientific Community .

The DDZ has around 240 employees and is closely linked to the Clinic for Endocrinology and Diabetology at the University Hospital Düsseldorf, the Institute for Metabolic Physiology and the Institute for Health Services Research and Health Economics at the HHU. The DDZ is also a founding partner in the German Center for Diabetes Research (DZD eV).

The DDZ conducts numerous clinical studies. The multicenter German Diabetes Study (GDS), which is carried out together with the partners and associated partners of the DZD eV, examines the metabolic changes of currently 1,500 people with diabetes mellitus from the first year after diagnosis and observes the course of comorbidities and long-term effects for at least ten years. Together with the Leibniz Institute for Environmental Medicine Research (IUF) Düsseldorf, the DDZ operates a study center for the NAKO health study , which examines 10,000 out of 200,000 people across Germany in order to enable improved prevention, early detection and diagnosis of common diseases such as cancer, diabetes and dementia. In addition, the DDZ runs a study on metabolic changes after bariatric surgery in people with obesity (BARIA-DDZ) and, since 1989, a population-based diabetes incidence register on the incidence of diabetes in children, adolescents and young adults, which is included in the Europe-wide cooperation project Find EURODIAB ACE on the epidemiology of type 1 diabetes.

The DDZ is financed equally by the Federal Ministry of Health (BMG) and the North Rhine-Westphalian Ministry of Culture and Science (MKW NRW) . In addition, projects are funded by the European Union (EU) , the German Research Foundation (DFG) and the Federal Ministry of Education and Research (BMBF) .

Research highlights

  • The German Diabetes Study (GDS) provided, among other things, indications of new subtypes (clusters) of diabetes with different risks for diabetes-associated diseases and complications. Scientists from the DDZ as well as partners from the DZD and the University of Lund have identified patients with severely insulin-resistant diabetes who have an increased risk of developing non-alcoholic fatty liver disease (NAFLD), while patients with severely insulin-deficient diabetes Diabetes have an increased risk of diabetic neuropathy. In accordance with the concept of precision medicine, these results should make it possible to develop prevention-tailored strategies for the prevention and treatment of diabetes and its consequences.
  • Liver dysfunction in obesity and diabetes is of increasing clinical and socio-economic importance. Scientists at the DDZ have recently contributed to a better understanding of energy metabolism at NAFLD (AG Prof. Roden) and to the mechanisms of liver regeneration (AG Prof. Lammert) in intensive cooperation.
  • Based on the data of around 65 million people with statutory health insurance and the Federal Statistical Office, the DDZ (AG Prof. Rathmann) published projections on the number of type 2 diabetes cases in Germany. One result of this project is a web-based tool (“diabetes watch”) that shows the prevalence and incidence of diabetes in Germany in real time.
  • Cardiovascular diseases are often associated with diabetes and contribute significantly to the increased mortality of patients. As part of a special research area SFB (1116) of the Medical Faculty at the HHU, which was set up by the DFG, scientists from the DDZ (Prof. Roden, PD Szendrödi) have been involved in researching the "Master switches in cardiac ischemia" since 2014 . The aim is to better understand and ultimately reduce the acute complications of myocardial infarction and its long-term consequences in connection with metabolic disorders such as diabetes mellitus.
  • The early changes that favor the development of diabetes mellitus are not yet exactly known. In the DFG-funded graduate college (GRK) "vivid - In vivo studies of the early development of type 2 diabetes" (Spokesperson: Prof. Al-Hasani), scientists from the natural sciences and medical faculties at the HHU conduct research in cooperation with the DDZ the mechanisms of the early causes of the development of diabetes.
  • The DDZ has been coordinating a competence center for innovative diabetes therapy (KomIT) since 2018 with the support of the state of North Rhine-Westphalia and the EU. A consortium of university and industrial partners aims to develop new therapies that are efficient and, above all, the rapid translation of innovative research results into clinical application.

From Mering Medal

Since 2016 the board of directors of the DDZ has been awarding the Von Mering Medal named after Josef von Mering to personalities who have been involved in German diabetes research and the DDZ for many years. Prize winners: 2016 Hans-Ulrich Häring, 2017 Hans-Georg Joost, 2018 Werner Waldhäusl, 2019 Guido Giani.

literature

  • OP Zaharia, K. Strassburger, A. Strom, GJ Bönhof, Y. Karusheva, S. Antoniou, K. Bódis, DF Markgraf, V. Burkart, K. Müssig, JH Hwang, O. Asplund, L. Groop, E. Ahlqvist, J. Seissler, P. Nawroth, S. Kopf, SM Schmid, M. Stumvoll, AFH Pfeiffer, S. Kabisch, S. Tselmin, HU Häring, D. Ziegler, O. Kuss, J. Szendroedi, M. Roden : Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study. In: Lancet Diabetes Endocrinol. Vol. 7, No. 9, 2019, pp. 657-736. doi: 10.1016 / S2213-8587 (19) 30187-1
  • M. Neuenschwander, A. Ballon, KS Weber, T. Norat, D. Aune, L. Schwingshackl, S. Schlesinger: Role of diet in type 2 diabetes prevention: umbrella review of meta-analyzes of prospective observational studies . In: BMJ 2019. doi: 10.1136 / bmj.l2368
  • L. Lorenz, J. Axnick, T. Buschmann, C. Henning, S. Urner, S. Fang, H. Nurmi, N. Eichhorst, R. Holtmeier, K. Bódis, JH Hwang, K. Müssig, D. Eberhard , J. Stypmann, O. Kuss, M. Roden, K. Alitalo, D. Häussinger, E. Lammert: Mechanosensing by β1 integrin induces angiocrine signals for liver growth and survival . In: Nature . 2018 Sep 26. doi: 10.1038 / s41586-018-0522-3
  • H. Claessen, T. Kvitkina, M. Narres, C. Trautner, I. Zöllner, B. Bertram, A. Icks: Markedly decreasing of blindness in people with and without diabetes in Southern Germany . In: Diabetes Care 2018; 41 (3): 478-484. doi: 10.2337 / dc17-2031
  • A. Chadt, A. Immisch, C. de Wendt, C. Springer, Z. Zhou, T. Stermann, GD Holman, D. Loffing-Cueni, J. Loffing, HG Joost, H. Al-Hasani: Deletion of both Rab-GTPase – activating proteins TBC1D1 and TBC1D4 in mice eliminates insulin- and AICAR-stimulated glucose transport . In: Diabetes . 2015 Mar; 64 (3): 746-59. doi: 10.2337 / db14-0368

Web links

Commons : German Diabetes Center  - Collection of images, videos and audio files

Individual evidence

  1. ^ German Diabetes Study - Looking for people with newly diagnosed diabetes. Retrieved March 30, 2020 .
  2. ^ Clinic for Endocrinology and Diabetology. Retrieved March 30, 2020 .
  3. ↑ https://ddz.de/de/impressum
  4. ↑ DZD partners at a glance. German Center for Diabetes Research, accessed on March 30, 2020 (German).
  5. ↑ Zaharia OP, Strassburger K, Strom A, Bönhof GJ, Karusheva Y, Antoniou S, Bódis K, Markgraf DF, Burkart V, Müssig K, Hwang JH, Asplund O, Groop L, Ahlqvist E, Seissler J, Nawroth P, Kopf S, Schmid SM, Stumvoll M, Pfeiffer AFH, Kabisch S, Tselmin S, Häring HU, Ziegler D, Kuss O, Szendroedi J, Roden M: Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5 -year follow-up study . In: The Lancet Diabetes & Endocrinology . tape 7 , no. 9 , September 2019, p. 684-694 , doi : 10.1016 / S2213-8587 (19) 30187-1 ( elsevier.com [accessed March 30, 2020]).
  6. ↑ Energy Metabolism Working Group. In: German Diabetes Center (DDZ). Accessed March 30, 2020 (German).
  7. ↑ Island Cell Research Group. In: German Diabetes Center (DDZ). Accessed March 30, 2020 (German).
  8. ↑ Epidemiology Working Group. In: German Diabetes Center (DDZ). Accessed March 30, 2020 (German).
  9. ↑ Diabetes watch. In: German Diabetes Center (DDZ). Accessed March 30, 2020 (German).
  10. ^ University of Düsseldorf: vivid. In: Heinrich Heine University Düsseldorf. Retrieved March 30, 2020 .
  11. ↑ New DFG Research Training Group : Vivid examines the early development of type 2 diabetes. In: German Diabetes Center (DDZ). November 11, 2019, accessed on March 30, 2020 (German).
  12. ↑ Projects. In: German Diabetes Center (DDZ). Accessed March 30, 2020 (German).
  13. ↑ State of North Rhine-Westphalia and the EU fund a new competence center for innovative diabetes therapy (KomIT). In: German Diabetes Center (DDZ). March 21, 2019, accessed on March 30, 2020 (German).
  14. ↑ DDZ opens new competence center for innovative diabetes therapy (KomIT) with eight partners. In: German Diabetes Center (DDZ). June 5, 2019, accessed on March 30, 2020 (German).
  15. ^ Center of Competence for Innovative Diabetes Therapy (KomIT) - Home. Accessed March 30, 2020 (German).
  16. ↑ Award: Von Mering Gold Medal to diabetes researcher, Prof. Dr. Hans-Ulrich Häring, awarded - German Diabetes Center (DDZ). Deutsche Diabetes-Forschungsgesellschaft eV, accessed on February 3, 2020 .
  17. ↑ Diabetes researcher Prof. Dr. Dr. Hans-Georg Joost awarded the Von Mering Gold Medal - German Diabetes Center (DDZ). Deutsche Diabetes-Forschungsgesellschaft eV, accessed on February 3, 2020 .
  18. ↑ Diabetes researcher Prof. Dr. Werner Waldhäusl receives the Von Mering Gold Medal from the German Diabetes Center - German Diabetes Center (DDZ). Deutsche Diabetes-Forschungsgesellschaft eV, accessed on February 3, 2020 .
  19. ↑ Prof. Dr. Guido Giani awarded the Von Mering Gold Medal from the German Diabetes Center - German Diabetes Center (DDZ). Deutsche Diabetes-Forschungsgesellschaft eV, accessed on February 3, 2020 .

Coordinates: 51 ° 12 '17.2 "  N , 6 ° 47' 14.6"  E